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@ARTICLE{Dereddi:285352,
      author       = {Dereddi, Ram R and Djannatian, Minou and Fiore, Frederic
                      and Kalita, Darshana and Verkest, Clement and Torres, Felipe
                      Bodaleo and Möbius, Wiebke and Khodaie, Babak and Ruhwedel,
                      Torben and Alhalaseh, Khaleel and Schifferer, Martina and
                      Wirth, Angela and Hill, Anthony and Ottenheijm, Roger and
                      Patrizi, Annarita and Kann, Oliver and Lechner, Stefan G and
                      Freichel, Marc and Agarwal, Amit},
      title        = {{O}ligodendrocyte mechanotransduction channel {TMEM}63{A}
                      regulates myelin sheath geometry.},
      journal      = {Neuron},
      volume       = {114},
      number       = {4},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DZNE-2026-00218},
      pages        = {699 - 723.e11},
      year         = {2026},
      abstract     = {Oligodendrocytes, the myelinating cells of the central
                      nervous system, precisely sculpt their insulating membranes
                      to match axon size, ensuring fine-tuned action potential
                      propagation. How oligodendrocytes estimate axon caliber to
                      adapt myelin sheath geometry is unknown. The biochemical
                      measure of axonal size provided by neuregulin 1 for Schwann
                      cells is dispensable in oligodendrocytes, and we reasoned
                      that biophysical cues might instead be required. By
                      combining transcriptomics, in vivo optical imaging, and
                      electron microscopy in mouse and zebrafish models, we
                      identified TMEM63A as a key mechanosensitive channel in
                      oligodendrocytes. TMEM63A enabled oligodendrocytes to sense
                      membrane stretch and translate it into Ca2+ signals. In the
                      absence of TMEM63A, developmental myelination was severely
                      impaired with shorter and thinner myelin sheaths on
                      large-diameter axons, ectopic myelination of very
                      small-diameter axons, and increased sheath retractions. We
                      propose MYO5A-dependent Mbp mRNA targeting to the nascent
                      myelin sheaths as a mechanism linking stretch-activated Ca2+
                      signaling to myelin formation and sheath geometry
                      refinement.},
      keywords     = {Animals / Myelin Sheath: metabolism / Myelin Sheath:
                      ultrastructure / Zebrafish / Mice / Mechanotransduction,
                      Cellular: physiology / Oligodendroglia: metabolism /
                      Oligodendroglia: ultrastructure / Axons: metabolism /
                      Zebrafish Proteins: genetics / Zebrafish Proteins:
                      metabolism / Calcium Signaling: physiology / Myelin Basic
                      Protein: metabolism / Myelin Basic Protein: genetics / HLD19
                      (Other) / MBP transport (Other) / TMEM63A (Other) /
                      axon-glia interactions (Other) / calcium signaling (Other) /
                      mechanical forces (Other) / mechanotransduction channels
                      (Other) / myelination (Other) / myosin5a (Other) /
                      oligodendrocyte (Other) / transient infantile
                      hypomyelinating leukodystrophy-19 (Other) / Zebrafish
                      Proteins (NLM Chemicals) / Myelin Basic Protein (NLM
                      Chemicals)},
      cin          = {AG Simons / AG Misgeld},
      ddc          = {610},
      cid          = {I:(DE-2719)1110008 / I:(DE-2719)1110000-4},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41483808},
      doi          = {10.1016/j.neuron.2025.11.009},
      url          = {https://pub.dzne.de/record/285352},
}