%0 Journal Article
%A Grazia, Alice
%A Levin, Fedor
%A Jessen, Frank
%A Wagner, Michael
%A Peters, Oliver
%A Priller, Josef
%A Schneider, Anja
%A Wiltfang, Jens
%A Düzel, Emrah
%A Buerger, Katharina
%A Perneczky, Robert
%A Laske, Christoph
%A Spottke, Annika
%A Ramirez, Alfredo
%A Teipel, Stefan J
%T Predicting longitudinal basal forebrain volume in the Alzheimer's disease spectrum: the role of sex and ApoE epsilon 4 genotype.
%J Frontiers in neuroscience
%V 20
%@ 1662-4548
%C Lausanne
%I Frontiers Research Foundation
%M DZNE-2026-00222
%P 1730947
%D 2026
%X Imaging studies showed early atrophy of the cholinergic basal forebrain (BF) already at prodromal stages of sporadic Alzheimer's disease (AD). Women and carriers of the ApoE epsilon 4 (ApoE ε4) allele are more likely to develop the disease; however, the underlying mechanisms are still unclear. Here we aimed at exploring the impact of sex and ApoE ε4 genotype in the AD spectrum on longitudinal measures of the basal forebrain and hippocampus, as a comparison region.We leveraged the German multi-centered study DELCODE and analyzed 712 individuals (median age: 71.25 years, interquartile range [IQR] = 9.22) with follow-up MRI scans (median time: 2.8 years, [IQR] = 1.75). Diagnostic groups comprised cognitively normal (N = 184), subjective cognitive decline (N = 331), mild cognitive impairment (N = 128) and AD (N = 69). Regarding ApoE genotype, 5
%K APOE ε4 (Other)
%K basal forebrain (Other)
%K hippocampus (Other)
%K homozygotes (Other)
%K sex-differences (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41716658
%2 pmc:PMC12913565
%R 10.3389/fnins.2026.1730947
%U https://pub.dzne.de/record/285356