TY  - JOUR
AU  - Grazia, Alice
AU  - Levin, Fedor
AU  - Jessen, Frank
AU  - Wagner, Michael
AU  - Peters, Oliver
AU  - Priller, Josef
AU  - Schneider, Anja
AU  - Wiltfang, Jens
AU  - Düzel, Emrah
AU  - Buerger, Katharina
AU  - Perneczky, Robert
AU  - Laske, Christoph
AU  - Spottke, Annika
AU  - Ramirez, Alfredo
AU  - Teipel, Stefan J
TI  - Predicting longitudinal basal forebrain volume in the Alzheimer's disease spectrum: the role of sex and ApoE epsilon 4 genotype.
JO  - Frontiers in neuroscience
VL  - 20
SN  - 1662-4548
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2026-00222
SP  - 1730947
PY  - 2026
AB  - Imaging studies showed early atrophy of the cholinergic basal forebrain (BF) already at prodromal stages of sporadic Alzheimer's disease (AD). Women and carriers of the ApoE epsilon 4 (ApoE ε4) allele are more likely to develop the disease; however, the underlying mechanisms are still unclear. Here we aimed at exploring the impact of sex and ApoE ε4 genotype in the AD spectrum on longitudinal measures of the basal forebrain and hippocampus, as a comparison region.We leveraged the German multi-centered study DELCODE and analyzed 712 individuals (median age: 71.25 years, interquartile range [IQR] = 9.22) with follow-up MRI scans (median time: 2.8 years, [IQR] = 1.75). Diagnostic groups comprised cognitively normal (N = 184), subjective cognitive decline (N = 331), mild cognitive impairment (N = 128) and AD (N = 69). Regarding ApoE genotype, 5
KW  - APOE ε4 (Other)
KW  - basal forebrain (Other)
KW  - hippocampus (Other)
KW  - homozygotes (Other)
KW  - sex-differences (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41716658
C2  - pmc:PMC12913565
DO  - DOI:10.3389/fnins.2026.1730947
UR  - https://pub.dzne.de/record/285356
ER  -