%0 Journal Article
%A Zhang, Ruiting
%A Chen, Chih-Hao
%A Lambert, Louis
%A Cheng, Yu-Wen
%A Lebenberg, Jessica
%A Tezenas Du Montcel, Sophie
%A Hervé, Dominique
%A Guey, Stephanie
%A Dichgans, Martin
%A Tang, Sung-Chun
%A Chabriat, Hugues
%T Simple MRI Lesion Levels Improve Two-Year Prognostic Accuracy Beyond Clinical History in CADASIL.
%J Stroke
%V 57
%N 3
%@ 0039-2499
%C New York, NY
%I Association
%M DZNE-2026-00223
%P 758 - 769
%D 2026
%X Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small-vessel disease. The CADASIL MRI Inventory Tool summarizes individual MRI findings as simple, type-specific lesion levels. We assessed the predictive value of these levels beyond clinical information.At baseline, CADASIL MRI Inventory Tool levels were assigned for periventricular, deep, and superficial white matter hyperintensities, lacunes, cerebral microbleeds, perivascular spaces in the centrum semiovale and basal ganglia, superficial and deep atrophy, large infarcts, and macrobleeds. Outcomes included stroke, migraine with aura (MA), moderate or severe cognitive impairment, and disability, which were assessed at baseline and during 2-year follow-up. Multivariable logistic regression was performed, with adjustment for age, sex, vascular risk factors, mutation location, and education level.We analyzed 743 patients from France, Germany, and Taiwan (mean age, 53±12; 55
%K Humans
%K CADASIL: diagnostic imaging
%K CADASIL: pathology
%K Male
%K Female
%K Middle Aged
%K Magnetic Resonance Imaging: methods
%K Prognosis
%K Adult
%K Aged
%K White Matter: diagnostic imaging
%K White Matter: pathology
%K Stroke
%K Cognitive Dysfunction
%K Atrophy
%K NOTCH3 mutation (Other)
%K cerebral atrophy (Other)
%K ischemic stroke (Other)
%K lacune (Other)
%K longitudinal (Other)
%K microbleed (Other)
%K white matter hyperintensities (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41439314
%R 10.1161/STROKEAHA.125.053727
%U https://pub.dzne.de/record/285357