TY  - JOUR
AU  - Zhang, Ruiting
AU  - Chen, Chih-Hao
AU  - Lambert, Louis
AU  - Cheng, Yu-Wen
AU  - Lebenberg, Jessica
AU  - Tezenas Du Montcel, Sophie
AU  - Hervé, Dominique
AU  - Guey, Stephanie
AU  - Dichgans, Martin
AU  - Tang, Sung-Chun
AU  - Chabriat, Hugues
TI  - Simple MRI Lesion Levels Improve Two-Year Prognostic Accuracy Beyond Clinical History in CADASIL.
JO  - Stroke
VL  - 57
IS  - 3
SN  - 0039-2499
CY  - New York, NY
PB  - Association
M1  - DZNE-2026-00223
SP  - 758 - 769
PY  - 2026
AB  - Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small-vessel disease. The CADASIL MRI Inventory Tool summarizes individual MRI findings as simple, type-specific lesion levels. We assessed the predictive value of these levels beyond clinical information.At baseline, CADASIL MRI Inventory Tool levels were assigned for periventricular, deep, and superficial white matter hyperintensities, lacunes, cerebral microbleeds, perivascular spaces in the centrum semiovale and basal ganglia, superficial and deep atrophy, large infarcts, and macrobleeds. Outcomes included stroke, migraine with aura (MA), moderate or severe cognitive impairment, and disability, which were assessed at baseline and during 2-year follow-up. Multivariable logistic regression was performed, with adjustment for age, sex, vascular risk factors, mutation location, and education level.We analyzed 743 patients from France, Germany, and Taiwan (mean age, 53±12; 55
KW  - Humans
KW  - CADASIL: diagnostic imaging
KW  - CADASIL: pathology
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Magnetic Resonance Imaging: methods
KW  - Prognosis
KW  - Adult
KW  - Aged
KW  - White Matter: diagnostic imaging
KW  - White Matter: pathology
KW  - Stroke
KW  - Cognitive Dysfunction
KW  - Atrophy
KW  - NOTCH3 mutation (Other)
KW  - cerebral atrophy (Other)
KW  - ischemic stroke (Other)
KW  - lacune (Other)
KW  - longitudinal (Other)
KW  - microbleed (Other)
KW  - white matter hyperintensities (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41439314
DO  - DOI:10.1161/STROKEAHA.125.053727
UR  - https://pub.dzne.de/record/285357
ER  -