%0 Journal Article
%A Eckenweber, Sebastian
%A Völter, Friederike
%A Franzmeier, Nicolai
%A Palleis, Carla
%A Wagemann, Olivia
%A Weidinger, Endy
%A Katzdobler, Sabrina
%A Wlasich, Elisabeth
%A Sandkühler, Katja
%A Böning, Guido
%A Gnoerich, Johannes
%A Scheifele, Maximilian
%A Eckenweber, Florian
%A Janowitz, Daniel
%A Kurz, Carolin
%A Perneczky, Robert
%A Bürger, Katharina
%A Danek, Adrian
%A Höglinger, Günter
%A Levin, Johannes
%A Brendel, Matthias
%A Schönecker, Sonja
%T Additive value of early-phase β-Amyloid-PET for the differential diagnosis of non-Alzheimer's disease dementia.
%J NeuroImage: Clinical
%V 49
%@ 2213-1582
%C [Amsterdam u.a.]
%I Elsevier
%M DZNE-2026-00225
%P 103963
%D 2026
%X Recent studies demonstrated strong agreement between early-phase β-amyloid-PET perfusion imaging and glucose hypometabolism assessed by [18F]FDG-PET, indicating the potential of early-phase β-amyloid-PET as a surrogate biomarker of neuronal injury. We therefore aimed to investigate the additive value of early-phase β-amyloid-PET for the differential diagnosis of non-Alzheimer's disease dementia syndromes in clinical routine.[18F]florbetaben- and [18F]flutemetamol-PET scans (n = 379) performed between July 2013 and July 2021 were analyzed for their amyloid status and the presence of a neurodegenerative hypoperfusion pattern using visual assessment and z-score maps. In patients visually rated as amyloid-negative/neurodegeneration-positive (A-N+), the most likely diagnosis based on perfusion patterns was compared to the final clinical diagnosis, i.e. frontotemporal dementia or psychiatric disorders, suspected 4R-tauopathy, and suspected non-Alzheimer pathophysiology. Logistic regression models based on a data-driven selection of cerebral regions of hypoperfusion by principal component analysis were used to predict neurodegenerative disease and clinical diagnoses. Diagnostic accuracy was compared between visual assessment and the regression models.Neurodegeneration status was correctly identified in 78.8
%K 4-repeattauopathy (Other)
%K Data driven (Other)
%K Early-phaseβ-amyloid-PET (Other)
%K Frontotemporal dementia (Other)
%K Multinomial logistic regression (Other)
%K Suspected non-Alzheimer pathophysiology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41690259
%2 pmc:PMC12925280
%R 10.1016/j.nicl.2026.103963
%U https://pub.dzne.de/record/285360