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000285369 1001_ $$aC. dos Santos, Jéssica$$b0
000285369 245__ $$aPersistent viral control status is associated with enhanced innate immune responses in people with HIV-1
000285369 260__ $$aSt. Louis$$bElsevier$$c2026
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000285369 520__ $$aThe mechanisms mediating elite and persistent HIV control in people living with HIV (PLHIV) are only partially understood and largely attributed to adaptive T cell responses, but whether innate immunity also contributes remains unclear. Using samples from the 2000HIV study, we examined the transcriptional and functional profiles of monocytes from spontaneous HIV controllers and normal progressors on long-term antiretroviral therapy. HIV controllers displayed enhanced cytokine production after bacterial and viral stimulation, alongside antiviral and interferon-inducible transcriptional signatures and reduced inflammatory gene expression. Persistent controllers further showed increased capacity for trained immunity, with H3K4me3 profiling indicating the epigenetic priming of innate immune genes. Remarkably, relatives of persistent controllers also exhibited stronger innate and trained immune responses than relatives of normal progressors. These findings suggest that robust innate immunity, particularly monocyte function, may precede infection and contribute to sustained HIV control, offering new avenues for therapies that induce similar innate antiviral responses.
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000285369 7001_ $$aGroenendijk, Albert L.$$b1
000285369 7001_ $$aRuijten, Suzanne D. E.$$b2
000285369 7001_ $$0P:(DE-2719)9000620$$aKnoll, Rainer$$b3$$udzne
000285369 7001_ $$aVadaq, Nadira$$b4
000285369 7001_ $$aHorst, Rob ter$$b5
000285369 7001_ $$aFok, Ezio T.$$b6
000285369 7001_ $$aWitkowski, Wojciech$$b7
000285369 7001_ $$aBlaauw, Marc J. T.$$b8
000285369 7001_ $$avan Eekeren, Louise E.$$b9
000285369 7001_ $$aVos, Wilhelm A. J. W.$$b10
000285369 7001_ $$aCleophas-Jacobs, Maartje$$b11
000285369 7001_ $$aReichl, Stephan$$b12
000285369 7001_ $$aOtten, Twan$$b13
000285369 7001_ $$aMartens, Joost H. A.$$b14
000285369 7001_ $$avan der Meer, Arnold$$b15
000285369 7001_ $$aKoninkx, Han$$b16
000285369 7001_ $$ade Jonge, Marien I.$$b17
000285369 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc D.$$b18$$udzne
000285369 7001_ $$avan Lunzen, Jan$$b19
000285369 7001_ $$aJoosten, Leo A. B.$$b20
000285369 7001_ $$aBock, Christoph$$b21
000285369 7001_ $$aRokx, Casper$$b22
000285369 7001_ $$aVerbon, Annelies$$b23
000285369 7001_ $$aVandekerckhove, Linos$$b24
000285369 7001_ $$0P:(DE-2719)2812913$$aAschenbrenner, Anna C.$$b25$$udzne
000285369 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L.$$b26$$udzne
000285369 7001_ $$aMatzaraki, Vasiliki$$b27
000285369 7001_ $$avan der Ven, Andre J. A. M.$$b28
000285369 7001_ $$aNetea, Mihai G.$$b29
000285369 773__ $$0PERI:(DE-600)2927064-9$$a10.1016/j.isci.2026.114807$$gVol. 29, no. 3, p. 114807 -$$n3$$p114807$$tiScience$$v29$$x2589-0042$$y2026
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