TY  - JOUR
AU  - C. dos Santos, Jéssica
AU  - Groenendijk, Albert L.
AU  - Ruijten, Suzanne D. E.
AU  - Knoll, Rainer
AU  - Vadaq, Nadira
AU  - Horst, Rob ter
AU  - Fok, Ezio T.
AU  - Witkowski, Wojciech
AU  - Blaauw, Marc J. T.
AU  - van Eekeren, Louise E.
AU  - Vos, Wilhelm A. J. W.
AU  - Cleophas-Jacobs, Maartje
AU  - Reichl, Stephan
AU  - Otten, Twan
AU  - Martens, Joost H. A.
AU  - van der Meer, Arnold
AU  - Koninkx, Han
AU  - de Jonge, Marien I.
AU  - Beyer, Marc D.
AU  - van Lunzen, Jan
AU  - Joosten, Leo A. B.
AU  - Bock, Christoph
AU  - Rokx, Casper
AU  - Verbon, Annelies
AU  - Vandekerckhove, Linos
AU  - Aschenbrenner, Anna C.
AU  - Schultze, Joachim L.
AU  - Matzaraki, Vasiliki
AU  - van der Ven, Andre J. A. M.
AU  - Netea, Mihai G.
TI  - Persistent viral control status is associated with enhanced innate immune responses in people with HIV-1
JO  - iScience
VL  - 29
IS  - 3
SN  - 2589-0042
CY  - St. Louis
PB  - Elsevier
M1  - DZNE-2026-00233
SP  - 114807
PY  - 2026
AB  - The mechanisms mediating elite and persistent HIV control in people living with HIV (PLHIV) are only partially understood and largely attributed to adaptive T cell responses, but whether innate immunity also contributes remains unclear. Using samples from the 2000HIV study, we examined the transcriptional and functional profiles of monocytes from spontaneous HIV controllers and normal progressors on long-term antiretroviral therapy. HIV controllers displayed enhanced cytokine production after bacterial and viral stimulation, alongside antiviral and interferon-inducible transcriptional signatures and reduced inflammatory gene expression. Persistent controllers further showed increased capacity for trained immunity, with H3K4me3 profiling indicating the epigenetic priming of innate immune genes. Remarkably, relatives of persistent controllers also exhibited stronger innate and trained immune responses than relatives of normal progressors. These findings suggest that robust innate immunity, particularly monocyte function, may precede infection and contribute to sustained HIV control, offering new avenues for therapies that induce similar innate antiviral responses.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1016/j.isci.2026.114807
UR  - https://pub.dzne.de/record/285369
ER  -