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@ARTICLE{CdosSantos:285369,
      author       = {C. dos Santos, Jéssica and Groenendijk, Albert L. and
                      Ruijten, Suzanne D. E. and Knoll, Rainer and Vadaq, Nadira
                      and Horst, Rob ter and Fok, Ezio T. and Witkowski, Wojciech
                      and Blaauw, Marc J. T. and van Eekeren, Louise E. and Vos,
                      Wilhelm A. J. W. and Cleophas-Jacobs, Maartje and Reichl,
                      Stephan and Otten, Twan and Martens, Joost H. A. and van der
                      Meer, Arnold and Koninkx, Han and de Jonge, Marien I. and
                      Beyer, Marc D. and van Lunzen, Jan and Joosten, Leo A. B.
                      and Bock, Christoph and Rokx, Casper and Verbon, Annelies
                      and Vandekerckhove, Linos and Aschenbrenner, Anna C. and
                      Schultze, Joachim L. and Matzaraki, Vasiliki and van der
                      Ven, Andre J. A. M. and Netea, Mihai G.},
      title        = {{P}ersistent viral control status is associated with
                      enhanced innate immune responses in people with {HIV}-1},
      journal      = {iScience},
      volume       = {29},
      number       = {3},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DZNE-2026-00233},
      pages        = {114807},
      year         = {2026},
      abstract     = {The mechanisms mediating elite and persistent HIV control
                      in people living with HIV (PLHIV) are only partially
                      understood and largely attributed to adaptive T cell
                      responses, but whether innate immunity also contributes
                      remains unclear. Using samples from the 2000HIV study, we
                      examined the transcriptional and functional profiles of
                      monocytes from spontaneous HIV controllers and normal
                      progressors on long-term antiretroviral therapy. HIV
                      controllers displayed enhanced cytokine production after
                      bacterial and viral stimulation, alongside antiviral and
                      interferon-inducible transcriptional signatures and reduced
                      inflammatory gene expression. Persistent controllers further
                      showed increased capacity for trained immunity, with H3K4me3
                      profiling indicating the epigenetic priming of innate immune
                      genes. Remarkably, relatives of persistent controllers also
                      exhibited stronger innate and trained immune responses than
                      relatives of normal progressors. These findings suggest that
                      robust innate immunity, particularly monocyte function, may
                      precede infection and contribute to sustained HIV control,
                      offering new avenues for therapies that induce similar
                      innate antiviral responses.},
      cin          = {AG Aschenbrenner / AG Beyer / AG Schultze / PRECISE},
      ddc          = {050},
      cid          = {I:(DE-2719)5000082 / I:(DE-2719)1013035 /
                      I:(DE-2719)1013038 / I:(DE-2719)1013031},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 351
                      - Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-351 /
                      G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.isci.2026.114807},
      url          = {https://pub.dzne.de/record/285369},
}