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000285463 1001_ $$0P:(DE-2719)9003133$$aLi, Qingyue$$b0$$udzne
000285463 245__ $$aExploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer's disease.
000285463 260__ $$aLondon$$bBioMed Central$$c2026
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000285463 520__ $$aDigital speech-based assessments provide scalable tools for detecting subtle cognitive decline. Here, we investigated whether digitally derived speech-based composite score of cognition and individual speech features were associated with alterations in functional connectivity (FC) within task-related brain networks in the Alzheimer's disease spectrum, which are known to reflect cognitive performance and disease-related changes.Data were analyzed from 129 participants of the German PROSPECT-AD study, ranging from cognitively healthy individuals to those with mild cognitive impairment. Speech-based cognitive scores and speech features were derived from automated phone-administered semantic verbal fluency (SVF) and verbal learning tasks (VLT). Resting-state fMRI assessed FC, with intrinsic connectivity networks identified via independent component analysis and dual regression. Associations were examined using permutation-based voxel-wise regression, controlling for demographic and clinical covariates. Seed-to-voxel analyses were conducted to support network identification and complement findings.Greater language network connectivity in the left middle temporal gyrus was associated with increased SVF temporal cluster switching (FWE < .05, cluster size = 12 voxels, mean T = 3.86). Exploratory analyses (uncorrected p < .01) demonstrated no significant associations between cognitive composite scores and FC. However, individual SVF and VLT speech features exhibited network-specific associations across executive, language, and default mode networks, indicating exploratory yet spatially distinct connectivity patterns.Digital speech-based assessments may have limited current utility for detecting FC alterations in at-risk individuals. Further validation using complementary methodological approaches, shorter intervals between fMRI and speech assessments, and testing in independent cohorts, are essential to establish their reliability and clinical relevance for monitoring brain network changes.
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000285463 650_7 $$2Other$$aAlzheimer’s disease spectrum
000285463 650_7 $$2Other$$aDigital assessment
000285463 650_7 $$2Other$$aFunctional MRI
000285463 650_7 $$2Other$$aMulticenter
000285463 650_7 $$2Other$$aSpeech
000285463 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
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000285463 7001_ $$aAlexopoulou, Zampeta-Sofia$$b1
000285463 7001_ $$0P:(DE-2719)2810283$$aDyrba, Martin$$b2$$udzne
000285463 7001_ $$aMallick, Elisa$$b3
000285463 7001_ $$aTröger, Johannes$$b4
000285463 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike$$b5$$udzne
000285463 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b6$$udzne
000285463 7001_ $$aBartels, Claudia$$b7
000285463 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b8$$udzne
000285463 7001_ $$0P:(DE-2719)9001517$$aIncesoy, Enise I$$b9$$udzne
000285463 7001_ $$0P:(DE-2719)9001011$$aButryn, Michaela$$b10$$udzne
000285463 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b11$$udzne
000285463 7001_ $$0P:(DE-2719)9003152$$aSodenkamp, Sebastian$$b12$$udzne
000285463 7001_ $$aMaier, Franziska$$b13
000285463 7001_ $$aRostamzadeh, Ayda$$b14
000285463 7001_ $$0P:(DE-2719)2810905$$aOsterrath, Antje$$b15$$udzne
000285463 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b16$$udzne
000285463 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b17$$udzne
000285463 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b18$$udzne
000285463 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b19$$udzne
000285463 7001_ $$0P:(DE-2719)2814178$$aFalkenburger, Björn$$b20$$udzne
000285463 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b21$$udzne
000285463 7001_ $$0P:(DE-2719)2000005$$aDuezel, Emrah$$b22$$udzne
000285463 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b23$$udzne
000285463 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b24$$udzne
000285463 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b25$$udzne
000285463 7001_ $$aKönig, Alexandra$$b26
000285463 7001_ $$0P:(DE-2719)2811683$$aKöhler, Stefanie$$b27$$udzne
000285463 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b28$$eLast author$$udzne
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000285463 773__ $$0PERI:(DE-600)2506521-X$$a10.1186/s13195-026-01993-x$$gVol. 18, no. 1, p. 52$$n1$$p52$$tAlzheimer's research & therapy$$v18$$x1758-9193$$y2026
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