TY  - JOUR
AU  - Jansen, Robin
AU  - Wagenhäuser, Markus U
AU  - Kölsche, Tristan
AU  - Papasimos, Cleopatra
AU  - Benkert, Pascal
AU  - Kuhle, Jens
AU  - Pawlitzki, Marc
AU  - Masanneck, Lars
AU  - Schreiber, Stefanie
AU  - Caspers, Julian
AU  - Ruck, Tobias
AU  - Hagler, Ramona
AU  - Stassen, Malin
AU  - Weiss, Daniel
AU  - Arndt, Philipp
AU  - Dörner, Marc
AU  - Mulorz, Joscha
AU  - Meuth, Sven G
AU  - Schelzig, Hubert
AU  - Lee, John-Ih
AU  - Gliem, Michael
TI  - Serum levels of neurofilament light chain (NfL) and glial fibrillary acid protein (GFAP) in patients with asymptomatic and symptomatic carotid artery stenosis.
JO  - JVS-vascular science
VL  - 7
SN  - 2666-3503
CY  - [Amsterdam]
PB  - Elsevier
M1  - DZNE-2026-00242
SP  - 100408
PY  - 2026
AB  - The treatment of carotid artery stenosis (CAS) for stroke prevention is a matter of debate due to conflicting data, missing recent data, and advances in medical treatment options but also in interventional techniques and surgery. Therefore, the establishment of an easily available marker for brain damage might be a key tool in this patient group to guide treatment.A retrospective cross-sectional study was conducted leveraging a vascular surgery biobank of 95 patients aged 60 to 80 years. Serum neurofilament light chain (sNfL) and serum glial fibrillary acid protein (sGFAP) were evaluated using highly sensitive electrochemiluminescence immunoassays and z-scores. Discriminatory performance was assessed to differentiate between 19 symptomatic and 76 asymptomatic patients with CAS and their correlation with the degree of stenosis according to ultrasound-based North American Symptomatic Carotid Endarterectomy Trial (NASCET) criteria.SNfL levels were markedly elevated in symptomatic compared with asymptomatic patients (median 17.4 vs 3.8 pg/mL; P < .001). sNfL robustly discriminated between these patients (area under the curve = 0.83; 95
KW  - Asymptomatic carotid artery stenosis (Other)
KW  - Risk stratification (Other)
KW  - Serum biomarker (Other)
KW  - Serum glial fibrillary acid protein (Other)
KW  - Serum neurofilament light chain (Other)
KW  - Stroke (Other)
KW  - Ultrasound (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41783480
C2  - pmc:PMC12954281
DO  - DOI:10.1016/j.jvssci.2026.100408
UR  - https://pub.dzne.de/record/285464
ER  -