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@ARTICLE{Marinescu:285472,
      author       = {Marinescu, Alina-Măriuca and Machado, Venissa and Pagano,
                      Gennaro and Muelhardt, Nicoletta Milani and Kustermann,
                      Thomas and Mracsko, Eva Zsuzsanna and Brockmann, Kathrin and
                      Shariati, Nima and Anzures-Cabrera, Judith and Zinnhardt,
                      Bastian},
      title        = {{C}erebrospinal {F}luid {B}iomarkers of {NLRP}3 {P}athway,
                      {I}mmune {D}ysregulation, and {N}eurodegeneration in
                      {P}arkinson's {D}isease: {A} {M}eta-{A}nalysis.},
      journal      = {Movement disorders},
      volume       = {41},
      number       = {2},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2026-00249},
      pages        = {466 - 477},
      year         = {2026},
      abstract     = {The activation of the NOD-, LRR- and pyrin
                      domain-containing protein 3 (NLRP3) inflammasome and
                      associated immune dysregulation is one of the key
                      pathological processes preceding and accompanying
                      α-synuclein pathology, neuronal damage, and cell death in
                      Parkinson's disease (PD). Biomarkers indicative of ongoing
                      immune dysregulation could potentially serve as early
                      indicators of disease activity and may support the
                      development of novel immunomodulatory therapies.We performed
                      a meta-analysis on 17 biomarkers related to specific
                      components of the neuroinflammatory response in the
                      cerebrospinal fluid of people with PD (PwP) and controls. We
                      included studies that measured biomarkers related to NLRP3
                      inflammasome priming and activation (interleukin [IL]-1β,
                      IL-18, IL-6, C-reactive protein, tumor necrosis factor
                      [TNF]-α); reactive glial cells (soluble triggering receptor
                      expressed on myeloid cells 2, chitinase 3-like-protein 1,
                      glial fibrillary acidic protein, and s100);
                      neurodegeneration (neurofilament light chain [NfL]); and
                      other inflammatory mediators (interferon-ɣ, IL-2, IL-4,
                      IL-8, IL-10, monocyte chemoattractant protein-1, chemokine
                      C-X3-C motif chemokine ligand 1).Random-effects
                      meta-analyses show markers downstream of the NLRP3
                      inflammasome priming and activation (IL-1β, IL-6, TNF-α),
                      the astrocytic marker s100 calcium-binding protein B and
                      neuroaxonal damage marker NfL are significantly increased in
                      the cerebrospinal fluid (CSF) of PwP.The elevation in key
                      downstream and general inflammatory mediators results is
                      consistent with the hypothesized involvement of the NLRP3
                      inflammasome pathway and neurodegeneration in PD
                      pathogenesis. These results highlight the potential use of
                      CSF inflammatory markers and support further investigation
                      into immunomodulatory strategies for PD. © 2025 The
                      Author(s). Movement Disorders published by Wiley Periodicals
                      LLC on behalf of International Parkinson and Movement
                      Disorder Society.},
      keywords     = {Humans / Parkinson Disease: cerebrospinal fluid / Parkinson
                      Disease: immunology / NLR Family, Pyrin Domain-Containing 3
                      Protein: cerebrospinal fluid / NLR Family, Pyrin
                      Domain-Containing 3 Protein: metabolism / NLR Family, Pyrin
                      Domain-Containing 3 Protein: immunology / Biomarkers:
                      cerebrospinal fluid / Inflammasomes / Biomarker (Other) /
                      CSF (Other) / Inflammation (Other) / NLRP3 (Other) /
                      Parkinson's disease (Other) / NLR Family, Pyrin
                      Domain-Containing 3 Protein (NLM Chemicals) / Biomarkers
                      (NLM Chemicals) / NLRP3 protein, human (NLM Chemicals) /
                      Inflammasomes (NLM Chemicals)},
      cin          = {AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41317029},
      pmc          = {pmc:PMC12951271},
      doi          = {10.1002/mds.70103},
      url          = {https://pub.dzne.de/record/285472},
}