%0 Journal Article
%A Gnörich, Johannes
%A Kusche-Palenga, Julia
%A Palleis, Carla
%A Neubauer, Antonia
%A Frontzkowski, Lukas
%A Jäck, Alexander
%A Kling, Agnes
%A Bauer, Theresa
%A Eyob, Hannah
%A Probst, Katharina
%A Roemer-Cassiano, Sebastian N
%A Bernhardt, Alexander M
%A Katzdobler, Sabrina
%A Marth, Lena
%A Zaganjori, Mirlind
%A Hopfner, Franziska
%A Zwergal, Andreas
%A Häckert, Jan
%A Rullmann, Michael
%A Sabri, Osama
%A Barthel, Henryk
%A Stöcklein, Sophia
%A Werner, Rudolf A
%A Simons, Mikael
%A Levin, Johannes
%A Herms, Jochen
%A Franzmeier, Nicolai
%A Höglinger, Günter U
%A Brendel, Matthias
%T Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI-2620 PET.
%J Alzheimer's and dementia
%V 22
%N 2
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2026-00255
%P e71195
%D 2026
%X Progressive supranuclear palsy (PSP), a 4-repeat tauopathy, can be visualized using [18F]PI-2620 tau positron emission tomography (PET). However, the value of sequential [18F]PI-2620 imaging for tracking tau accumulation during the disease course has not yet been investigated.Twenty-three PSP patients underwent two [18F]PI-2620 PET scans (interval: 21.4 ± 4.3 months) and were compared to cross-sectional data from 25 healthy controls. Regional volume of distribution ratio values were analyzed for longitudinal tau changes, clinical correlations, and network-based propagation. Post mortem analyses examined neuronal density and AT8 tau pathology.Subcortical tau PET signals increased, strongest in the globus pallidus internus (P < 0.0001). Patients with low baseline tau showed the largest increases. Despite clinical worsening (Progressive Supranuclear Palsy Rating Scale +48
%K Humans
%K Supranuclear Palsy, Progressive: diagnostic imaging
%K Supranuclear Palsy, Progressive: metabolism
%K Supranuclear Palsy, Progressive: pathology
%K Positron-Emission Tomography
%K tau Proteins: metabolism
%K Male
%K Female
%K Aged
%K Longitudinal Studies
%K Middle Aged
%K Disease Progression
%K Brain: diagnostic imaging
%K Brain: metabolism
%K Brain: pathology
%K Cross-Sectional Studies
%K Fluorine Radioisotopes
%K Pyridines
%K 4‐repeat tauopathies (Other)
%K disease monitoring (Other)
%K progressive supranuclear palsy (Other)
%K tau positron emission tomography (Other)
%K tau spreading (Other)
%K tau Proteins (NLM Chemicals)
%K Fluorine Radioisotopes (NLM Chemicals)
%K PI-2620 (NLM Chemicals)
%K Pyridines (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41736364
%2 pmc:PMC12932912
%R 10.1002/alz.71195
%U https://pub.dzne.de/record/285478