TY  - JOUR
AU  - Gnörich, Johannes
AU  - Kusche-Palenga, Julia
AU  - Palleis, Carla
AU  - Neubauer, Antonia
AU  - Frontzkowski, Lukas
AU  - Jäck, Alexander
AU  - Kling, Agnes
AU  - Bauer, Theresa
AU  - Eyob, Hannah
AU  - Probst, Katharina
AU  - Roemer-Cassiano, Sebastian N
AU  - Bernhardt, Alexander M
AU  - Katzdobler, Sabrina
AU  - Marth, Lena
AU  - Zaganjori, Mirlind
AU  - Hopfner, Franziska
AU  - Zwergal, Andreas
AU  - Häckert, Jan
AU  - Rullmann, Michael
AU  - Sabri, Osama
AU  - Barthel, Henryk
AU  - Stöcklein, Sophia
AU  - Werner, Rudolf A
AU  - Simons, Mikael
AU  - Levin, Johannes
AU  - Herms, Jochen
AU  - Franzmeier, Nicolai
AU  - Höglinger, Günter U
AU  - Brendel, Matthias
TI  - Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI-2620 PET.
JO  - Alzheimer's and dementia
VL  - 22
IS  - 2
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2026-00255
SP  - e71195
PY  - 2026
AB  - Progressive supranuclear palsy (PSP), a 4-repeat tauopathy, can be visualized using [18F]PI-2620 tau positron emission tomography (PET). However, the value of sequential [18F]PI-2620 imaging for tracking tau accumulation during the disease course has not yet been investigated.Twenty-three PSP patients underwent two [18F]PI-2620 PET scans (interval: 21.4 ± 4.3 months) and were compared to cross-sectional data from 25 healthy controls. Regional volume of distribution ratio values were analyzed for longitudinal tau changes, clinical correlations, and network-based propagation. Post mortem analyses examined neuronal density and AT8 tau pathology.Subcortical tau PET signals increased, strongest in the globus pallidus internus (P < 0.0001). Patients with low baseline tau showed the largest increases. Despite clinical worsening (Progressive Supranuclear Palsy Rating Scale +48
KW  - Humans
KW  - Supranuclear Palsy, Progressive: diagnostic imaging
KW  - Supranuclear Palsy, Progressive: metabolism
KW  - Supranuclear Palsy, Progressive: pathology
KW  - Positron-Emission Tomography
KW  - tau Proteins: metabolism
KW  - Male
KW  - Female
KW  - Aged
KW  - Longitudinal Studies
KW  - Middle Aged
KW  - Disease Progression
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Brain: pathology
KW  - Cross-Sectional Studies
KW  - Fluorine Radioisotopes
KW  - Pyridines
KW  - 4‐repeat tauopathies (Other)
KW  - disease monitoring (Other)
KW  - progressive supranuclear palsy (Other)
KW  - tau positron emission tomography (Other)
KW  - tau spreading (Other)
KW  - tau Proteins (NLM Chemicals)
KW  - Fluorine Radioisotopes (NLM Chemicals)
KW  - PI-2620 (NLM Chemicals)
KW  - Pyridines (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41736364
C2  - pmc:PMC12932912
DO  - DOI:10.1002/alz.71195
UR  - https://pub.dzne.de/record/285478
ER  -