000285480 001__ 285480
000285480 005__ 20260309113113.0
000285480 0247_ $$2doi$$a10.3389/frbis.2025.1681011
000285480 037__ $$aDZNE-2026-00257
000285480 041__ $$aEnglish
000285480 082__ $$a570
000285480 1001_ $$0P:(DE-2719)9003352$$aStratmann, Maite$$b0$$eFirst author$$udzne
000285480 245__ $$aProton channel Hv1 modulates microglial responses to neurological disorders
000285480 260__ $$aLausanne$$bFrontiers Media SA$$c2025
000285480 3367_ $$2DRIVER$$aarticle
000285480 3367_ $$2DataCite$$aOutput Types/Journal article
000285480 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1773047231_14565
000285480 3367_ $$2BibTeX$$aARTICLE
000285480 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000285480 3367_ $$00$$2EndNote$$aJournal Article
000285480 520__ $$aProton channels are transmembrane proteins that enable selective proton (H+) transport. The voltage-gated proton channel Hv1 or HVCN1 is the only one found in mammalian cells, primarily in immune cells, where it facilitates rapid proton extrusion in response to membrane depolarization, mediating outward proton currents. Therefore, it is well equipped to support NADPH-oxidase function, facilitating the proton flux that maintains physiological pH and membrane potential for efficient reactive oxygen species (ROS) production. In the central nervous system (CNS), Hv1 is predominantly found in microglia. Its role in microglia homeostasis is yet to be elucidated; however, recent research has highlighted its involvement in neurological conditions, including demyelinating disease, spinal cord injury, stroke, and Parkinsonism. These studies have shown beneficial effects of Hv1 deletion, including improved neurological function, reduced microglial activation, enhanced myelination, and decreased neuroinflammation. This review explores the role of Hv1 in the CNS and its potential as a therapeutic target in neurodegenerative diseases.
000285480 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000285480 588__ $$aDataset connected to CrossRef, Journals: pub.dzne.de
000285480 7001_ $$0P:(DE-2719)9002154$$aGagliardi, Caterina$$b1$$udzne
000285480 7001_ $$0P:(DE-2719)2811780$$aCapasso, Melania$$b2$$eLast author$$udzne
000285480 773__ $$0PERI:(DE-600)3223746-7$$a10.3389/frbis.2025.1681011$$gVol. 3, p. 1681011$$p1681011$$tFrontiers in biophysics$$v3$$x2813-7183$$y2025
000285480 8564_ $$uhttps://pub.dzne.de/record/285480/files/DZNE-2026-00257.pdf$$yOpenAccess
000285480 8564_ $$uhttps://pub.dzne.de/record/285480/files/DZNE-2026-00257.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000285480 8767_ $$92025-09-26$$a#745$$c90.00 CHF$$d2026-03-09$$eAPC$$jDeposit$$lFrontiers
000285480 909CO $$ooai:pub.dzne.de:285480$$pdnbdelivery$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire
000285480 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9003352$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000285480 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002154$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000285480 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811780$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000285480 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000285480 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000285480 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2025-08-24T13:44:29Z
000285480 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2025-08-24T13:44:29Z
000285480 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000285480 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2025-08-24T13:44:29Z
000285480 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2025-11-12
000285480 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-11-12
000285480 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2025-11-12
000285480 915pc $$0PC:(DE-HGF)0000$$2APC$$aAPC keys set
000285480 915pc $$0PC:(DE-HGF)0001$$2APC$$aLocal Funding
000285480 915pc $$0PC:(DE-HGF)0002$$2APC$$aDFG OA Publikationskosten
000285480 915pc $$0PC:(DE-HGF)0003$$2APC$$aDOAJ Journal
000285480 9201_ $$0I:(DE-2719)1013033$$kAG Capasso$$lImmune Regulation$$x0
000285480 980__ $$ajournal
000285480 980__ $$aVDB
000285480 980__ $$aUNRESTRICTED
000285480 980__ $$aI:(DE-2719)1013033
000285480 980__ $$aAPC
000285480 9801_ $$aAPC
000285480 9801_ $$aFullTexts