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@ARTICLE{Fuxjger:285491,
      author       = {Fuxjäger, Isabelle S and Antons, Melissa and Marouane,
                      Emna and Leschiutta, Giulia and Oos, Rosel and Palumbo,
                      Giovanna and Steenken, Dilara and Lindner, Simon and
                      Ziegler, Sibylle and Bartenstein, Peter and Brendel,
                      Matthias and Werner, Rudolf and Zwergal, Andreas},
      title        = {{L}ongitudinal comparison of adaptive neuroplasticity in
                      two rat models of unilateral vestibulopathy by dual-tracer
                      [18{F}]{FDG} and [18{F}]{UCB}-{H} {PET}.},
      journal      = {NeuroImage},
      volume       = {329},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2026-00267},
      pages        = {121821},
      year         = {2026},
      abstract     = {Animal models of acute unilateral vestibulopathy are well
                      established for the study of adaptive lesion-induced
                      neuroplasticity, because symptoms of acute vestibular
                      asymmetry such as nystagmus and postural imbalance recover
                      over time as central vestibular compensation mechanisms
                      commence action. The purpose of this study was to compare
                      these mechanisms in a postganglionic complete unilateral
                      vestibular neurectomy model (UVN) vs. a preganglionic
                      incomplete chemical unilateral labyrinthectomy model (cUL)
                      using a longitudinal [18F]FDG/[18F]UCB-H dual tracer
                      positron emission tomography (PET) approach accompanied by
                      multimodal behavioral testing. Twenty-four male Sprague
                      Dawley rats underwent either cUL or UVN. Postoperatively,
                      [18F]FDG PETs were conducted weekly for four weeks to depict
                      changes of [18F]FDG as a surrogate for functional
                      plasticity, and [18F]UCB-H PETs were carried out at three
                      time points over nine weeks to visualize alterations in
                      synaptic density indicating structural plasticity.
                      Behavioral recovery was assessed weekly using a clinical
                      scoring system and open field evaluation. Behavioral data
                      reflected comparable compensation dynamics between groups.
                      Both [18F]FDG and [18F]UCB-H PET revealed a similar spatial
                      pattern of brain regions involved in adaptive
                      neuroplasticity. However, while the relative extent of
                      [18F]FDG uptake in these networks was comparable across both
                      models, synaptic density changes were more pronounced in UVN
                      vs. cUL. Specifically, synaptic density in the vestibular
                      nuclei was significantly lower after UVN, accompanied by a
                      more intense compensatory increase in sensorimotor cortical
                      areas. In conclusion, synaptic density imaging may be a more
                      sensitive method to depict subtle differences in mechanisms
                      of lesion-induced adaptive neuroplasticity than traditional
                      techniques such as imaging of glucose metabolism.},
      keywords     = {Acute unilateral vestibulopathy (Other) / Animal models
                      (Other) / Dizziness (Other) / Neuroimaging (Other) /
                      Synaptic density (Other) / Unilateral chemical
                      labyrinthectomy (Other) / Unilateral vestibular neurectomy
                      (Other) / Vertigo (Other)},
      cin          = {AG Haass},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41722883},
      doi          = {10.1016/j.neuroimage.2026.121821},
      url          = {https://pub.dzne.de/record/285491},
}