%0 Journal Article
%A Asperger, Hannah
%A Bode, Felix
%A Ebrahimi, Taraneh
%A Kindler, Christine
%A Layer, Julia
%A Meißner, Julius Nicolai
%A Nitsch, Louisa
%A Shirvani, Omid
%A Thielscher, Christian
%A von Danwitz, Niklas Michael
%A Weller, Johannes
%A Dorn, Franziska
%A Petzold, Gabor C
%A Stösser, Sebastian
%T Impact of Severe Prestroke Disability on Outcomes After Mechanical Thrombectomy: A Multicenter Analysis.
%J Stroke: vascular and interventional neurology
%V 6
%N 1
%@ 2694-5746
%C Dallas, Tex.
%I American Heart Association, National Center
%M DZNE-2026-00270
%P e002055
%D 2026
%X Patients with severe prestroke disability (PSD) remain underrepresented in mechanical thrombectomy studies, despite their growing relevance in aging populations. This study used data from the German Stroke Registry-Endovascular Treatment to evaluate functional recovery, mortality, and poststroke care outcomes in this high-risk population.We analyzed 9456 mechanical thrombectomy-treated patients with stroke from the German Stroke Registry-Endovascular Treatment (2015-2021), categorized by premorbid modified Rankin Scale (mRS): no PSD (mRS score, 0-1), moderate PSD (mPSD; mRS score, 2-3), and severe PSD (sPSD; mRS score, 4-5). Favorable outcomes were defined as an mRS score of 0 to 2 or return to baseline. Logistic regression adjusted for age, National Institutes of Health Stroke Scale, intravenous thrombolysis, reperfusion success, and sex was used to predict outcomes. A neural network subsequently explored feature importance.Among 9456 patients, 7387 had no PSD, 1648 mPSD, and 421 sPSD. Unadjusted 90-day outcomes showed increasing mortality with PSD severity and fewer favorable outcomes in both PSD groups. At 90 days, favorable outcomes occurred in 3020 patients without PSD (40.9
%K dementia (Other)
%K patient discharge (Other)
%K sample size (Other)
%K stroke (Other)
%K thrombectomy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41816510
%2 pmc:PMC12959425
%R 10.1161/SVIN.125.002055
%U https://pub.dzne.de/record/285631