TY  - JOUR
AU  - Asperger, Hannah
AU  - Bode, Felix
AU  - Ebrahimi, Taraneh
AU  - Kindler, Christine
AU  - Layer, Julia
AU  - Meißner, Julius Nicolai
AU  - Nitsch, Louisa
AU  - Shirvani, Omid
AU  - Thielscher, Christian
AU  - von Danwitz, Niklas Michael
AU  - Weller, Johannes
AU  - Dorn, Franziska
AU  - Petzold, Gabor C
AU  - Stösser, Sebastian
TI  - Impact of Severe Prestroke Disability on Outcomes After Mechanical Thrombectomy: A Multicenter Analysis.
JO  - Stroke: vascular and interventional neurology
VL  - 6
IS  - 1
SN  - 2694-5746
CY  - Dallas, Tex.
PB  - American Heart Association, National Center
M1  - DZNE-2026-00270
SP  - e002055
PY  - 2026
AB  - Patients with severe prestroke disability (PSD) remain underrepresented in mechanical thrombectomy studies, despite their growing relevance in aging populations. This study used data from the German Stroke Registry-Endovascular Treatment to evaluate functional recovery, mortality, and poststroke care outcomes in this high-risk population.We analyzed 9456 mechanical thrombectomy-treated patients with stroke from the German Stroke Registry-Endovascular Treatment (2015-2021), categorized by premorbid modified Rankin Scale (mRS): no PSD (mRS score, 0-1), moderate PSD (mPSD; mRS score, 2-3), and severe PSD (sPSD; mRS score, 4-5). Favorable outcomes were defined as an mRS score of 0 to 2 or return to baseline. Logistic regression adjusted for age, National Institutes of Health Stroke Scale, intravenous thrombolysis, reperfusion success, and sex was used to predict outcomes. A neural network subsequently explored feature importance.Among 9456 patients, 7387 had no PSD, 1648 mPSD, and 421 sPSD. Unadjusted 90-day outcomes showed increasing mortality with PSD severity and fewer favorable outcomes in both PSD groups. At 90 days, favorable outcomes occurred in 3020 patients without PSD (40.9
KW  - dementia (Other)
KW  - patient discharge (Other)
KW  - sample size (Other)
KW  - stroke (Other)
KW  - thrombectomy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41816510
C2  - pmc:PMC12959425
DO  - DOI:10.1161/SVIN.125.002055
UR  - https://pub.dzne.de/record/285631
ER  -