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@ARTICLE{Vogel:285634,
      author       = {Vogel, Adam P and Graf, Lisa and Weiß, Merit and Chan,
                      Cheuk S J and Hepworth, Graham and Synofzik, Matthis},
      title        = {{D}evelopment and validation of the dysarthria impact
                      scale: a patient-reported outcome for motor speech
                      disorders.},
      journal      = {Journal of neurology},
      volume       = {273},
      number       = {3},
      issn         = {0367-004X},
      address      = {[Darmstadt]},
      publisher    = {Steinkopff},
      reportid     = {DZNE-2026-00273},
      pages        = {195},
      year         = {2026},
      abstract     = {Impaired speech due to dysarthria significantly impacts
                      quality of life. Patient-reported outcomes (PROs) offer
                      critical insight into the lived experience of communication
                      disability and are central to regulatory frameworks for
                      patient-focused drug development.To develop and validate the
                      Dysarthria Impact Scale (DIS), a brief PRO designed to
                      assess the impact of motor speech disorders on quality of
                      life across neurological conditions.A multi-site,
                      cross-sectional study was conducted with 244 participants,
                      including individuals with Huntington's disease, Parkinson's
                      disease, hereditary ataxias, and head and neck cancer, and
                      healthy controls. The 22-item DIS was developed using expert
                      input and patient feedback and evaluated alongside reference
                      tools (Voice Handicap Index and SF-36). Item reduction
                      procedures yielded two shorter versions (DIS-17 and DIS-6).
                      Validity, reliability, and sensitivity/specificity analyses
                      were performed, and minimal clinically important differences
                      (MCIDs) were estimated using distribution-based methods.All
                      DIS versions showed strong convergent validity with the VHI
                      (r = -0.85) and SF-36 (r = 0.72) and were correlated with
                      blinded perceptual speech ratings. DIS-17 and DIS-6 achieved
                      comparable sensitivity (0.93 and 0.88) and specificity (0.84
                      and 0.86, respectively). Test-retest reliability was high (r
                      = 0.98), with estimated MCIDs and within-subject variability
                      provided. Group differences were observed, with lower DIS
                      scores in ataxia and Parkinson's disease compared to
                      Huntington's disease.The DIS is a valid, reliable, and
                      practical PRO for quantifying the impact of dysarthria on
                      quality of life. Longitudinal responsiveness remains to be
                      established.},
      keywords     = {Humans / Dysarthria: diagnosis / Dysarthria: etiology /
                      Dysarthria: psychology / Male / Female / Middle Aged /
                      Patient Reported Outcome Measures / Aged / Cross-Sectional
                      Studies / Adult / Reproducibility of Results / Quality of
                      Life / Severity of Illness Index / Clinical trials (Other) /
                      Dysarthria (Other) / Patient-reported outcome (Other) /
                      Questionnaire (Other) / Speech (Other) / Survey (Other)},
      cin          = {AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41805906},
      pmc          = {pmc:PMC12975812},
      doi          = {10.1007/s00415-026-13740-1},
      url          = {https://pub.dzne.de/record/285634},
}