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000285725 1001_ $$00000-0001-6486-8261$$aKoprivec, Isabella$$b0
000285725 245__ $$aPolar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting.
000285725 260__ $$a[London]$$bSpringer Nature$$c2026
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000285725 520__ $$aPolar chromosomes, which initially attach to the mitotic spindle behind the pole, are prone to missegregation and micronuclear entrapment, contributing to chromosomal instability in cancer. Yet, the mechanisms ensuring their faithful segregation remain unclear. Here, we show that polar chromosomes require a unique step involving spindle elongation, which repositions chromosome-bound astral microtubules by pivoting them around the centrosome toward the spindle surface. By modulating Eg5/KIF11 activity, we demonstrate that spindle elongation determines the direction and extent of pivoting, with microtubules from the opposite spindle half facilitating final movement. Kinetochores on polar chromosomes form mono-lateral attachments, recruiting corona components and partially Mad2, but lacking Astrin. In cancer cell lines, limited spindle elongation delays polar chromosome resolution, whereas enhanced elongation accelerates it. These findings highlight the role of spindle elongation in the timely rescue of chromosomes from the 'danger zone' behind the pole, providing mechanistic insight into chromosome congression errors in cancer.
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000285725 650_7 $$0EC 3.6.4.4$$2NLM Chemicals$$aKinesins
000285725 650_7 $$2NLM Chemicals$$aKIF11 protein, human
000285725 650_7 $$2NLM Chemicals$$aMad2 Proteins
000285725 650_2 $$2MeSH$$aHumans
000285725 650_2 $$2MeSH$$aSpindle Apparatus: metabolism
000285725 650_2 $$2MeSH$$aChromosome Segregation
000285725 650_2 $$2MeSH$$aMicrotubules: metabolism
000285725 650_2 $$2MeSH$$aKinetochores: metabolism
000285725 650_2 $$2MeSH$$aKinesins: metabolism
000285725 650_2 $$2MeSH$$aKinesins: genetics
000285725 650_2 $$2MeSH$$aHeLa Cells
000285725 650_2 $$2MeSH$$aMad2 Proteins: metabolism
000285725 650_2 $$2MeSH$$aCell Line, Tumor
000285725 650_2 $$2MeSH$$aChromosomes, Human: metabolism
000285725 650_2 $$2MeSH$$aCentrosome: metabolism
000285725 650_2 $$2MeSH$$aChromosomal Instability
000285725 7001_ $$0P:(DE-2719)9003585$$aStimac, Valentina$$b1$$eFirst author$$udzne
000285725 7001_ $$00009-0002-5237-3522$$aĐura, Mario$$b2
000285725 7001_ $$00000-0002-4867-6080$$aVukušić, Kruno$$b3
000285725 7001_ $$00009-0001-1930-6865$$aMikec, Petra$$b4
000285725 7001_ $$00000-0003-1305-7922$$aTolić, Iva M$$b5
000285725 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-026-69830-1$$gVol. 17, no. 1, p. 2049$$n1$$p2049$$tNature Communications$$v17$$x2041-1723$$y2026
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