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@ARTICLE{Koprivec:285725,
      author       = {Koprivec, Isabella and Stimac, Valentina and Đura, Mario
                      and Vukušić, Kruno and Mikec, Petra and Tolić, Iva M},
      title        = {{P}olar chromosomes are rescued from missegregation by
                      spindle elongation-driven microtubule pivoting.},
      journal      = {Nature Communications},
      volume       = {17},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2026-00282},
      pages        = {2049},
      year         = {2026},
      abstract     = {Polar chromosomes, which initially attach to the mitotic
                      spindle behind the pole, are prone to missegregation and
                      micronuclear entrapment, contributing to chromosomal
                      instability in cancer. Yet, the mechanisms ensuring their
                      faithful segregation remain unclear. Here, we show that
                      polar chromosomes require a unique step involving spindle
                      elongation, which repositions chromosome-bound astral
                      microtubules by pivoting them around the centrosome toward
                      the spindle surface. By modulating Eg5/KIF11 activity, we
                      demonstrate that spindle elongation determines the direction
                      and extent of pivoting, with microtubules from the opposite
                      spindle half facilitating final movement. Kinetochores on
                      polar chromosomes form mono-lateral attachments, recruiting
                      corona components and partially Mad2, but lacking Astrin. In
                      cancer cell lines, limited spindle elongation delays polar
                      chromosome resolution, whereas enhanced elongation
                      accelerates it. These findings highlight the role of spindle
                      elongation in the timely rescue of chromosomes from the
                      'danger zone' behind the pole, providing mechanistic insight
                      into chromosome congression errors in cancer.},
      keywords     = {Humans / Spindle Apparatus: metabolism / Chromosome
                      Segregation / Microtubules: metabolism / Kinetochores:
                      metabolism / Kinesins: metabolism / Kinesins: genetics /
                      HeLa Cells / Mad2 Proteins: metabolism / Cell Line, Tumor /
                      Chromosomes, Human: metabolism / Centrosome: metabolism /
                      Chromosomal Instability / Kinesins (NLM Chemicals) / KIF11
                      protein, human (NLM Chemicals) / Mad2 Proteins (NLM
                      Chemicals)},
      cin          = {AG Bradke},
      ddc          = {500},
      cid          = {I:(DE-2719)1013002},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41844586},
      pmc          = {pmc:PMC12996568},
      doi          = {10.1038/s41467-026-69830-1},
      url          = {https://pub.dzne.de/record/285725},
}