Home > In process > Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting. > print

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024 7 _ |a 10.1038/s41467-026-69830-1
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100 1 _ |a Koprivec, Isabella
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245 _ _ |a Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting.
260 _ _ |a [London]
|c 2026
|b Springer Nature
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520 _ _ |a Polar chromosomes, which initially attach to the mitotic spindle behind the pole, are prone to missegregation and micronuclear entrapment, contributing to chromosomal instability in cancer. Yet, the mechanisms ensuring their faithful segregation remain unclear. Here, we show that polar chromosomes require a unique step involving spindle elongation, which repositions chromosome-bound astral microtubules by pivoting them around the centrosome toward the spindle surface. By modulating Eg5/KIF11 activity, we demonstrate that spindle elongation determines the direction and extent of pivoting, with microtubules from the opposite spindle half facilitating final movement. Kinetochores on polar chromosomes form mono-lateral attachments, recruiting corona components and partially Mad2, but lacking Astrin. In cancer cell lines, limited spindle elongation delays polar chromosome resolution, whereas enhanced elongation accelerates it. These findings highlight the role of spindle elongation in the timely rescue of chromosomes from the 'danger zone' behind the pole, providing mechanistic insight into chromosome congression errors in cancer.
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650 _ 7 |a Kinesins
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650 _ 7 |a KIF11 protein, human
|2 NLM Chemicals
650 _ 7 |a Mad2 Proteins
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Spindle Apparatus: metabolism
|2 MeSH
650 _ 2 |a Chromosome Segregation
|2 MeSH
650 _ 2 |a Microtubules: metabolism
|2 MeSH
650 _ 2 |a Kinetochores: metabolism
|2 MeSH
650 _ 2 |a Kinesins: metabolism
|2 MeSH
650 _ 2 |a Kinesins: genetics
|2 MeSH
650 _ 2 |a HeLa Cells
|2 MeSH
650 _ 2 |a Mad2 Proteins: metabolism
|2 MeSH
650 _ 2 |a Cell Line, Tumor
|2 MeSH
650 _ 2 |a Chromosomes, Human: metabolism
|2 MeSH
650 _ 2 |a Centrosome: metabolism
|2 MeSH
650 _ 2 |a Chromosomal Instability
|2 MeSH
700 1 _ |a Stimac, Valentina
|0 P:(DE-2719)9003585
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700 1 _ |a Đura, Mario
|0 0009-0002-5237-3522
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700 1 _ |a Vukušić, Kruno
|0 0000-0002-4867-6080
|b 3
700 1 _ |a Mikec, Petra
|0 0009-0001-1930-6865
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700 1 _ |a Tolić, Iva M
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773 _ _ |a 10.1038/s41467-026-69830-1
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