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@ARTICLE{Hesse:285733,
      author       = {Hesse, Swen and Schiefer, Manja and Tiepolt, Solveig and
                      Prochnow, Dorit and Mämecke, Larissa and Hoffmann, Frank
                      and Schniewind, Inaki and Sabri, Osama and Falkenburger,
                      Björn and Brock, Sebastian},
      title        = {{A}n {MSA}-{P} patient presenting with preserved glucose
                      metabolism in the putamen, cerebellar hypometabolism and
                      pronounced loss of presynaptic dopamine transporter in the
                      striatum.},
      journal      = {EJNMMI reports},
      volume       = {10},
      number       = {1},
      issn         = {3005-074X},
      address      = {[Cham]},
      publisher    = {Springer International Publishing},
      reportid     = {DZNE-2026-00290},
      pages        = {10},
      year         = {2026},
      abstract     = {Positron emission tomography (PET) of the brain using
                      [18F]fluorodeoxyglucose (FDG) is becoming increasingly
                      important for the diagnosis and differential diagnosis of
                      atypical parkinsonian syndrome such as multiple system
                      atrophy (MSA), which is characterized by hypometabolism of
                      the putamen, pons, and cerebellum. We report on a patient
                      with clinically established MSA based on a rapidly
                      progressive, poorly levodopa-responsive parkinsonian
                      syndrome, multidomain autonomic failure, and imaging
                      findings where hereditary spastic paraplegia was discussed
                      as a differential diagnosis. PET images revealed a
                      well-preserved glucose metabolism in the striatum,
                      specifically in the putamen, while metabolism in the
                      cerebellum was significantly reduced. This pattern of
                      glucose metabolism might indicate a distinct subtype of
                      synucleinopathy as proven by seed-amplification assay and
                      should be taken into account when diagnosing patients with
                      MSA.},
      keywords     = {Dopamine transporter (Other) / FDG (Other) / MSA (Other) /
                      Multiple system atrophy (Other) / PET (Other) / Parkinsonian
                      syndrome (Other) / Putamen (Other) / SPECT (Other) / SPG
                      (Other) / [18F]fluorodeoxyglucose (Other)},
      cin          = {AG Falkenburger},
      ddc          = {610},
      cid          = {I:(DE-2719)1710012},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41857168},
      doi          = {10.1186/s41824-026-00294-8},
      url          = {https://pub.dzne.de/record/285733},
}