Home > In process > An MSA-P patient presenting with preserved glucose metabolism in the putamen, cerebellar hypometabolism and pronounced loss of presynaptic dopamine transporter in the striatum. > print

001     285733
005     20260320145541.0
024 7 _ |a 10.1186/s41824-026-00294-8
|2 doi
024 7 _ |a pmid:41857168
|2 pmid
037 _ _ |a DZNE-2026-00290
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Hesse, Swen
|0 0000-0002-2055-2764
|b 0
245 _ _ |a An MSA-P patient presenting with preserved glucose metabolism in the putamen, cerebellar hypometabolism and pronounced loss of presynaptic dopamine transporter in the striatum.
260 _ _ |a [Cham]
|c 2026
|b Springer International Publishing
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Positron emission tomography (PET) of the brain using [18F]fluorodeoxyglucose (FDG) is becoming increasingly important for the diagnosis and differential diagnosis of atypical parkinsonian syndrome such as multiple system atrophy (MSA), which is characterized by hypometabolism of the putamen, pons, and cerebellum. We report on a patient with clinically established MSA based on a rapidly progressive, poorly levodopa-responsive parkinsonian syndrome, multidomain autonomic failure, and imaging findings where hereditary spastic paraplegia was discussed as a differential diagnosis. PET images revealed a well-preserved glucose metabolism in the striatum, specifically in the putamen, while metabolism in the cerebellum was significantly reduced. This pattern of glucose metabolism might indicate a distinct subtype of synucleinopathy as proven by seed-amplification assay and should be taken into account when diagnosing patients with MSA.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Dopamine transporter
|2 Other
650 _ 7 |a FDG
|2 Other
650 _ 7 |a MSA
|2 Other
650 _ 7 |a Multiple system atrophy
|2 Other
650 _ 7 |a PET
|2 Other
650 _ 7 |a Parkinsonian syndrome
|2 Other
650 _ 7 |a Putamen
|2 Other
650 _ 7 |a SPECT
|2 Other
650 _ 7 |a SPG
|2 Other
650 _ 7 |a [18F]fluorodeoxyglucose
|2 Other
700 1 _ |a Schiefer, Manja
|b 1
700 1 _ |a Tiepolt, Solveig
|b 2
700 1 _ |a Prochnow, Dorit
|b 3
700 1 _ |a Mämecke, Larissa
|b 4
700 1 _ |a Hoffmann, Frank
|b 5
700 1 _ |a Schniewind, Inaki
|0 P:(DE-2719)9000748
|b 6
700 1 _ |a Sabri, Osama
|0 P:(DE-2719)2814810
|b 7
|u dzne
700 1 _ |a Falkenburger, Björn
|0 P:(DE-2719)2814178
|b 8
|u dzne
700 1 _ |a Brock, Sebastian
|b 9
773 _ _ |a 10.1186/s41824-026-00294-8
|g Vol. 10, no. 1, p. 10
|0 PERI:(DE-600)3181214-4
|n 1
|p 10
|t EJNMMI reports
|v 10
|y 2026
|x 3005-074X
856 4 _ |u https://pub.dzne.de/record/285733/files/DZNE-2026-00290.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
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910 1 _ |a External Institute
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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|l Neurodegenerative Diseases
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|v Clinical and Health Care Research
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920 1 _ |0 I:(DE-2719)1710012
|k AG Falkenburger
|l Translational Parkinson Research
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980 _ _ |a journal
980 _ _ |a EDITORS
980 _ _ |a VDBINPRINT
980 _ _ |a I:(DE-2719)1710012
980 _ _ |a UNRESTRICTED

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