%0 Journal Article
%A Wagemann, Olivia
%A Götz, Charlotte
%A Wlasich, Elisabeth
%A Sandkühler, Katja
%A Prix, Catharina
%A Stockbauer, Anna
%A Marth, Lena
%A Jäck, Alexander
%A Halbgebauer, Steffen
%A Tumani, Hayrettin
%A Höglinger, Günter U
%A Levin, Johannes
%A Nübling, Georg
%T Combining blood biomarkers and the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-G) for diagnosing cognitive decline in Down syndrome.
%J Alzheimer's and dementia
%V 22
%N 3
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2026-00291
%P e71296
%D 2026
%X Individuals with Down syndrome (DS) are at risk for Alzheimer's disease (AD). However, diagnosis remains challenging due to variability of intellectual ability and symptom presentation. To investigate whether serum AD biomarkers enhance accuracy of the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-G), we combined test scores with neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) levels.Seventy-eight DS individuals (49
%K Humans
%K Down Syndrome: complications
%K Down Syndrome: blood
%K Female
%K Male
%K Biomarkers: blood
%K Neurofilament Proteins: blood
%K Middle Aged
%K Cognitive Dysfunction: diagnosis
%K Cognitive Dysfunction: blood
%K Surveys and Questionnaires
%K Glial Fibrillary Acidic Protein: blood
%K Germany
%K Intellectual Disability: blood
%K Intellectual Disability: complications
%K Aged
%K Dementia: diagnosis
%K Dementia: blood
%K Adult
%K Alzheimer's disease (Other)
%K Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (Other)
%K Down syndrome (Other)
%K blood biomarker (Other)
%K glial fibrillary acidic protein (Other)
%K neurofilament light chain (Other)
%K screening (Other)
%K Biomarkers (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%K neurofilament protein L (NLM Chemicals)
%K Glial Fibrillary Acidic Protein (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41859776
%R 10.1002/alz.71296
%U https://pub.dzne.de/record/285734