TY  - JOUR
AU  - Wagemann, Olivia
AU  - Götz, Charlotte
AU  - Wlasich, Elisabeth
AU  - Sandkühler, Katja
AU  - Prix, Catharina
AU  - Stockbauer, Anna
AU  - Marth, Lena
AU  - Jäck, Alexander
AU  - Halbgebauer, Steffen
AU  - Tumani, Hayrettin
AU  - Höglinger, Günter U
AU  - Levin, Johannes
AU  - Nübling, Georg
TI  - Combining blood biomarkers and the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-G) for diagnosing cognitive decline in Down syndrome.
JO  - Alzheimer's and dementia
VL  - 22
IS  - 3
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2026-00291
SP  - e71296
PY  - 2026
AB  - Individuals with Down syndrome (DS) are at risk for Alzheimer's disease (AD). However, diagnosis remains challenging due to variability of intellectual ability and symptom presentation. To investigate whether serum AD biomarkers enhance accuracy of the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-G), we combined test scores with neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) levels.Seventy-eight DS individuals (49
KW  - Humans
KW  - Down Syndrome: complications
KW  - Down Syndrome: blood
KW  - Female
KW  - Male
KW  - Biomarkers: blood
KW  - Neurofilament Proteins: blood
KW  - Middle Aged
KW  - Cognitive Dysfunction: diagnosis
KW  - Cognitive Dysfunction: blood
KW  - Surveys and Questionnaires
KW  - Glial Fibrillary Acidic Protein: blood
KW  - Germany
KW  - Intellectual Disability: blood
KW  - Intellectual Disability: complications
KW  - Aged
KW  - Dementia: diagnosis
KW  - Dementia: blood
KW  - Adult
KW  - Alzheimer's disease (Other)
KW  - Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (Other)
KW  - Down syndrome (Other)
KW  - blood biomarker (Other)
KW  - glial fibrillary acidic protein (Other)
KW  - neurofilament light chain (Other)
KW  - screening (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41859776
DO  - DOI:10.1002/alz.71296
UR  - https://pub.dzne.de/record/285734
ER  -