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@ARTICLE{Wagemann:285734,
      author       = {Wagemann, Olivia and Götz, Charlotte and Wlasich,
                      Elisabeth and Sandkühler, Katja and Prix, Catharina and
                      Stockbauer, Anna and Marth, Lena and Jäck, Alexander and
                      Halbgebauer, Steffen and Tumani, Hayrettin and Höglinger,
                      Günter U and Levin, Johannes and Nübling, Georg},
      title        = {{C}ombining blood biomarkers and the {G}erman version of
                      the {D}ementia {S}creening {Q}uestionnaire for {I}ndividuals
                      with {I}ntellectual {D}isabilities ({DSQIID}-{G}) for
                      diagnosing cognitive decline in {D}own syndrome.},
      journal      = {Alzheimer's and dementia},
      volume       = {22},
      number       = {3},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2026-00291},
      pages        = {e71296},
      year         = {2026},
      abstract     = {Individuals with Down syndrome (DS) are at risk for
                      Alzheimer's disease (AD). However, diagnosis remains
                      challenging due to variability of intellectual ability and
                      symptom presentation. To investigate whether serum AD
                      biomarkers enhance accuracy of the German version of the
                      Dementia Screening Questionnaire for Individuals with
                      Intellectual Disabilities (DSQIID-G), we combined test
                      scores with neurofilament light chain (NfL) and glial
                      fibrillary acidic protein (GFAP) levels.Seventy-eight DS
                      individuals $(49\%$ female) completed the DSQIID-G; previous
                      cohort data were added for a pooled sample (n = 164, $47\%$
                      female). Serum NfL and GFAP were assessed using the
                      automated microfluid Ella system.Combining the DSQIID-G with
                      NfL or GFAP resulted in improved accuracy in every
                      diagnostic subgroup. The Youden index in the pooled samples
                      yielded a cut-off score at 6.5.The DSQIID-G is a robust
                      screening tool and its combination with AD blood biomarkers
                      aids earlier identification of individuals requiring further
                      diagnostics for DS-associated AD.},
      keywords     = {Humans / Down Syndrome: complications / Down Syndrome:
                      blood / Female / Male / Biomarkers: blood / Neurofilament
                      Proteins: blood / Middle Aged / Cognitive Dysfunction:
                      diagnosis / Cognitive Dysfunction: blood / Surveys and
                      Questionnaires / Glial Fibrillary Acidic Protein: blood /
                      Germany / Intellectual Disability: blood / Intellectual
                      Disability: complications / Aged / Dementia: diagnosis /
                      Dementia: blood / Adult / Alzheimer's disease (Other) /
                      Dementia Screening Questionnaire for Individuals with
                      Intellectual Disabilities (Other) / Down syndrome (Other) /
                      blood biomarker (Other) / glial fibrillary acidic protein
                      (Other) / neurofilament light chain (Other) / screening
                      (Other) / Biomarkers (NLM Chemicals) / Neurofilament
                      Proteins (NLM Chemicals) / neurofilament protein L (NLM
                      Chemicals) / Glial Fibrillary Acidic Protein (NLM
                      Chemicals)},
      cin          = {Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41859776},
      doi          = {10.1002/alz.71296},
      url          = {https://pub.dzne.de/record/285734},
}