TY  - JOUR
AU  - Zhunussova, Alina
AU  - Loane, Clare
AU  - Kurt, Elif
AU  - Femminella, Grazia Daniela
AU  - Lenzoni, Sabrina
AU  - Duckett, Millie
AU  - Callaghan, Martina F
AU  - Weiskopf, Nikolaus
AU  - Dolan, Raymond J
AU  - Howard, Robert
AU  - Düzel, Emrah
AU  - Hämmerer, Dorothea
TI  - Pupil dilation as a marker of attention/effort in aging and mild cognitive impairment.
JO  - Alzheimer's and dementia
VL  - 22
IS  - 3
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2026-00295
SP  - e71180
PY  - 2026
AB  - Pupil dilation (PD) can be easily measured and reflects responses to subjectively salient or cognitively demanding events. It therefore holds promise as a cognitive marker, especially for individuals with mild cognitive impairment (MCI) or other neurodegenerative conditions with restricted abilities to respond in cognitive assessments.We assessed PD during two tasks, an oddball task for investigating attentional allocation and a Simon task, which additionally allows for investigating cognitive effort in younger adults (YAs), older adults (OAs), and patients with MCI.PD is a useful marker for investigating attention and cognitive effort in MCI, as suggested by elevated PD to salient stimuli in particular of individuals with better attentional control in MCI patients, as well as YAs and OAs.Measurement of PD may serve as an easy-to-administer measure to assess changes in cognitive function in healthy aging and MCI.
KW  - Humans
KW  - Cognitive Dysfunction: physiopathology
KW  - Cognitive Dysfunction: diagnosis
KW  - Male
KW  - Female
KW  - Aged
KW  - Pupil: physiology
KW  - Attention: physiology
KW  - Aging: physiology
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Adult
KW  - Young Adult
KW  - Aged, 80 and over
KW  - attentional modulation (Other)
KW  - cognitive effort (Other)
KW  - locus coeruleus (Other)
KW  - mild cognitive impairment (Other)
KW  - pupil dilation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41830112
DO  - DOI:10.1002/alz.71180
UR  - https://pub.dzne.de/record/285738
ER  -