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024 7 _ |a 10.1002/alz.71180
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037 _ _ |a DZNE-2026-00295
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Zhunussova, Alina
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245 _ _ |a Pupil dilation as a marker of attention/effort in aging and mild cognitive impairment.
260 _ _ |a Hoboken, NJ
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520 _ _ |a Pupil dilation (PD) can be easily measured and reflects responses to subjectively salient or cognitively demanding events. It therefore holds promise as a cognitive marker, especially for individuals with mild cognitive impairment (MCI) or other neurodegenerative conditions with restricted abilities to respond in cognitive assessments.We assessed PD during two tasks, an oddball task for investigating attentional allocation and a Simon task, which additionally allows for investigating cognitive effort in younger adults (YAs), older adults (OAs), and patients with MCI.PD is a useful marker for investigating attention and cognitive effort in MCI, as suggested by elevated PD to salient stimuli in particular of individuals with better attentional control in MCI patients, as well as YAs and OAs.Measurement of PD may serve as an easy-to-administer measure to assess changes in cognitive function in healthy aging and MCI.
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650 _ 7 |a attentional modulation
|2 Other
650 _ 7 |a cognitive effort
|2 Other
650 _ 7 |a locus coeruleus
|2 Other
650 _ 7 |a mild cognitive impairment
|2 Other
650 _ 7 |a pupil dilation
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: physiopathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: diagnosis
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Pupil: physiology
|2 MeSH
650 _ 2 |a Attention: physiology
|2 MeSH
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
700 1 _ |a Loane, Clare
|b 1
700 1 _ |a Kurt, Elif
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700 1 _ |a Femminella, Grazia Daniela
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700 1 _ |a Lenzoni, Sabrina
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700 1 _ |a Duckett, Millie
|b 5
700 1 _ |a Callaghan, Martina F
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700 1 _ |a Weiskopf, Nikolaus
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700 1 _ |a Dolan, Raymond J
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700 1 _ |a Howard, Robert
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700 1 _ |a Düzel, Emrah
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700 1 _ |a Hämmerer, Dorothea
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773 _ _ |a 10.1002/alz.71180
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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