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@ARTICLE{Hasoon:285740,
      author       = {Hasoon, Jahfer and Hamilton, Calum A and Firbank, Michael
                      and Schumacher, Julia and Colloby, Sean J and Donaghy, Paul
                      C and Taylor, John-Paul and Thomas, Alan J},
      title        = {{M}ultimodal biomarkers to predict dementia-free survival
                      and cognitive decline in mild cognitive impairment with
                      {L}ewy bodies.},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {145},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2026-00297},
      pages        = {108265},
      year         = {2026},
      abstract     = {Predicting conversion to dementia in mild cognitive
                      impairment with Lewy bodies (MCI-LB) remains challenging.
                      Furthermore, there is limited research combining predictive
                      markers in MCI-LB. We explored the utility of Lewy body and
                      Alzheimer's disease biomarkers for the prediction of future
                      decline in MCI-LB.Eighty-seven participants were included
                      (35 MCI-AD, 15 possible MCI-LB, 37 probable MCI-LB).
                      Baseline assessment involved MRI, EEG, bloods and cognitive
                      testing. Follow up was completed yearly with review of
                      diagnosis and repeat cognitive testing. We evaluated the
                      relationship between baseline biomarkers and dementia-free
                      survival time. We also investigated biomarker effects on
                      future cognitive decline using annualised change in ACE-R.
                      The value of combining biomarkers with baseline cognitive
                      test score was assessed using forward selection.In probable
                      MCI-LB, shorter dementia-free survival time was strongly
                      associated with smaller hippocampal volume (hazard ratio =
                      2.36, $95\%$ CI 1.41 - 3.94) and smaller posterior cortical
                      volume (hazard ratio = 2.62, $95\%$ CI 1.35 - 5.10). Reduced
                      EEG dominant frequency, increased relative delta and theta
                      power, reduced insula volume, increased plasma tau, and
                      increased plasma GFAP were also associated with an increased
                      hazard ratio. Posterior atrophy, hippocampal atrophy, and
                      GFAP were significant predictors of ACE-R decline. Combining
                      blood and MRI biomarkers improved model quality for
                      dementia-free survival (GFAP and hippocampal atrophy) and
                      cognitive test decline (AB ratio and posterior
                      atrophy).Blood, EEG and MRI biomarkers of dementia with Lewy
                      bodies, neurodegeneration and Alzheimer's co-pathology
                      demonstrate utility for prognosis in MCI-LB. Combining
                      biomarkers across modalities improves prognostic accuracy.},
      keywords     = {Dementia with lewy bodies (Other) / Disease progression
                      (Other) / EEG (Other) / MRI (Other) / Mild cognitive
                      impairment (Other) / Plasma biomarkers (Other)},
      cin          = {AG Storch},
      ddc          = {610},
      cid          = {I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41780490},
      doi          = {10.1016/j.parkreldis.2026.108265},
      url          = {https://pub.dzne.de/record/285740},
}