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@ARTICLE{Faber:285805,
      author       = {Faber, Jennifer and Paech, Daniel and Pracht, Eberhard and
                      Stirnberg, Rüdiger and Ehses, Philipp and Völzke, Yannik
                      and Löwen, Daniel and Ferreira, Mónica and Brunheim,
                      Sascha and Boulant, Nicolas and Gras, Vincent and
                      Mauconduit, Franck and Massire, Aurélien and Goa, Pal Erik
                      and Lamalle, Laurent and Rüber, Theodor and Bauer, Tobias
                      and Petzold, Gabor C and Nordsiek, Julia and Schneider,
                      Matthias and Schaub, Christina and Klockgether, Thomas and
                      Radbruch, Alexander and Stöcker, Tony},
      title        = {{R}eady for {R}outine: {H}omogeneous, {H}igh-{R}esolution,
                      and {M}ulticontrast {W}hole-{B}rain {MRI} at 7 {T}esla in
                      {S}hort {S}can {T}ime {W}ith 'plug-and-{P}lay' p{T}x
                      {S}equences.},
      journal      = {Investigative radiology},
      volume       = {Advance online publication},
      issn         = {0020-9996},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {DZNE-2026-00341},
      pages        = {-},
      year         = {2025},
      abstract     = {7T MRI received FDA/CE clearance almost 7 years ago.
                      However, until today, it has not yet been widely adopted in
                      clinical routine. This is mainly due to field
                      inhomogeneities that impede whole-brain coverage. Moreover,
                      the long scan times often associated with high-resolution
                      imaging are an additional limiting factor.To combine
                      calibration-free parallel transmit technology (pTx) using
                      universal pulses (UP) with advanced imaging acceleration
                      strategies to achieve homogenous multicontrast 7T MRI with
                      whole-brain coverage and high spatial resolution in short
                      scan time.Ten healthy volunteers were scanned both with
                      conventional vendor-provided sequences and with custom
                      sequences for anatomical whole-brain imaging [-weighted,
                      -weighted, FLAIR, and susceptibility-weighted]. The scan
                      times for the 2 anatomical protocols were matched (25
                      minutes). In addition, a quantitative MRI protocol
                      [multi-parametric mapping (MPM) and chemical exchange
                      saturation transfer (CEST)] was scanned twice using custom
                      sequences with conventional (circular polarized) and UPs,
                      respectively, in a scan time of 2×25 minutes. Moreover, 4
                      patients with different neurological diseases were scanned,
                      namely temporal lobe epilepsy, spinocerebellar ataxia,
                      cerebral amyloid angiopathy, and glioblastoma. For the
                      patients, only optimized custom sequences with UPs were
                      acquired.Compared with conventional implementations, the
                      custom sequences provide strongly improved image homogeneity
                      and quality with significantly higher SNR and CNR across the
                      whole brain, including cerebellum and brain stem. Moreover,
                      UPs improve the repeatability of derived quantitative
                      parameters. The suggested protocol has additionally been
                      successfully demonstrated in 4 patients with different
                      neurological pathologies.Homogeneous whole-brain 7T MRI with
                      high spatial resolution and high image quality is possible
                      in clinically feasible scan times. The developed protocol
                      can be applied without any expert knowledge and is ready for
                      clinical use. The approach could largely extend
                      applicability of UHF MRI in neuroradiology paving the way
                      for increased routine use of 7T MRI.},
      keywords     = {7 Tesla (Other) / 7T (Other) / CEST (Other) / MPM (Other) /
                      MPRAGE (Other) / infratentorial structures (Other) /
                      neuroradiology (Other) / pTx (Other) / ultra-high field
                      (Other)},
      cin          = {AG Stöcker / Clinical Research (Bonn) / AG Radbruch / AG
                      Petzold / Patient Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1013026 / I:(DE-2719)1011001 /
                      I:(DE-2719)5000075 / I:(DE-2719)1013020 /
                      I:(DE-2719)1011101},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 353
                      - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41416735},
      doi          = {10.1097/RLI.0000000000001252},
      url          = {https://pub.dzne.de/record/285805},
}