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000285806 005__ 20260401140558.0
000285806 0247_ $$2doi$$a10.1109/EMBC58623.2025.11253841
000285806 0247_ $$2pmid$$apmid:41337179
000285806 037__ $$aDZNE-2026-00342
000285806 041__ $$aEnglish
000285806 1001_ $$0P:(DE-2719)9001361$$aEmery, Brett Addison$$b0$$eFirst author$$udzne
000285806 1112_ $$a47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society$$cCopenhagen$$d2025-07-14 - 2025-07-18$$gEMBC$$wDenmark
000285806 245__ $$aSpatiotemporal Mapping of Epileptiform Dynamics in the Hippocampal Circuit via High-Density Biosensors.
000285806 260__ $$bIEEE$$c2025
000285806 29510 $$a2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : [Proceedings] - IEEE, 2025. - ISBN 979-8-3315-8618-8 - doi:10.1109/EMBC58623.2025.11253841
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000285806 3367_ $$0PUB:(DE-HGF)8$$2PUB:(DE-HGF)$$aContribution to a conference proceedings$$bcontrib$$mcontrib$$s1775044992_19839
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000285806 500__ $$aMissing Journal: Annu Int Conf IEEE Eng Med Biol Soc = 2375-7477 (import from CrossRef Conference, PubMed, , Journals: pub.dzne.de)
000285806 520__ $$a70 million people suffer from epilepsy worldwide with temporal lobe epilepsy (TLE) being the most common focal epilepsy in adults. The hippocampus, a region associated with TLE, is highly susceptible to pathological synchronization and epileptogenesis due to its functional and anatomical organization. Despite progress, understanding the distinct contributions of hippocampal subregions to multiplexed activation and hyperactivity remains challenging due to the interplay of receptor dynamics, ion channel regulation, and network synchronization. Here, a large-scale ex-vivo electrophysiological platform was implemented using a high-density CMOS-based biosensor (HD-MEA) to probe the spatiotemporal dynamics of 4AP and ATPA, benchmark compounds for inducing hyperactivity, within the hippocampal circuit. This approach demonstrates the use of large-scale biosensors to address these challenges by enabling high-resolution spatiotemporal mapping of circuit activity, demonstrating their potential to uncover ion channel and receptor-specific spatiotemporal signatures of hyperactivity.
000285806 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000285806 588__ $$aDataset connected to CrossRef Conference, PubMed, , Journals: pub.dzne.de
000285806 650_2 $$2MeSH$$aBiosensing Techniques: methods
000285806 650_2 $$2MeSH$$aBiosensing Techniques: instrumentation
000285806 650_2 $$2MeSH$$aHippocampus: physiopathology
000285806 650_2 $$2MeSH$$aAnimals
000285806 650_2 $$2MeSH$$aEpilepsy: physiopathology
000285806 650_2 $$2MeSH$$aEpilepsy, Temporal Lobe: physiopathology
000285806 650_2 $$2MeSH$$aSpatio-Temporal Analysis
000285806 650_2 $$2MeSH$$aHumans
000285806 7001_ $$0P:(DE-2719)9001867$$aKhanzada, Shahrukh$$b1$$udzne
000285806 7001_ $$0P:(DE-2719)2814182$$aHu, Xin$$b2$$udzne
000285806 7001_ $$0P:(DE-2719)2812628$$aAmin, Hayder$$b3$$eLast author$$udzne
000285806 773__ $$a10.1109/EMBC58623.2025.11253841
000285806 8564_ $$uhttps://pub.dzne.de/record/285806/files/DZNE-2026-00342_Restricted.pdf
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000285806 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001361$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000285806 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001867$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000285806 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814182$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000285806 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812628$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000285806 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000285806 9201_ $$0I:(DE-2719)1710010$$kAG Amin$$lBiohybrid Neuroelectronics (BIONICS)$$x0
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