TY  - CONF
AU  - Emery, Brett Addison
AU  - Khanzada, Shahrukh
AU  - Hu, Xin
AU  - Amin, Hayder
TI  - Spatiotemporal Mapping of Epileptiform Dynamics in the Hippocampal Circuit via High-Density Biosensors.
PB  - IEEE
M1  - DZNE-2026-00342
SP  - 1-4
PY  - 2025
N1  - Missing Journal: Annu Int Conf IEEE Eng Med Biol Soc = 2375-7477 (import from CrossRef Conference, PubMed, , Journals: pub.dzne.de)
AB  - 70 million people suffer from epilepsy worldwide with temporal lobe epilepsy (TLE) being the most common focal epilepsy in adults. The hippocampus, a region associated with TLE, is highly susceptible to pathological synchronization and epileptogenesis due to its functional and anatomical organization. Despite progress, understanding the distinct contributions of hippocampal subregions to multiplexed activation and hyperactivity remains challenging due to the interplay of receptor dynamics, ion channel regulation, and network synchronization. Here, a large-scale ex-vivo electrophysiological platform was implemented using a high-density CMOS-based biosensor (HD-MEA) to probe the spatiotemporal dynamics of 4AP and ATPA, benchmark compounds for inducing hyperactivity, within the hippocampal circuit. This approach demonstrates the use of large-scale biosensors to address these challenges by enabling high-resolution spatiotemporal mapping of circuit activity, demonstrating their potential to uncover ion channel and receptor-specific spatiotemporal signatures of hyperactivity.
T2  - 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CY  - 14 Jul 2025 - 18 Jul 2025, Copenhagen (Denmark)
Y2  - 14 Jul 2025 - 18 Jul 2025
M2  - Copenhagen, Denmark
KW  - Biosensing Techniques: methods
KW  - Biosensing Techniques: instrumentation
KW  - Hippocampus: physiopathology
KW  - Animals
KW  - Epilepsy: physiopathology
KW  - Epilepsy, Temporal Lobe: physiopathology
KW  - Spatio-Temporal Analysis
KW  - Humans
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
C6  - pmid:41337179
DO  - DOI:10.1109/EMBC58623.2025.11253841
UR  - https://pub.dzne.de/record/285806
ER  -