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@INPROCEEDINGS{Emery:285806,
      author       = {Emery, Brett Addison and Khanzada, Shahrukh and Hu, Xin and
                      Amin, Hayder},
      title        = {{S}patiotemporal {M}apping of {E}pileptiform {D}ynamics in
                      the {H}ippocampal {C}ircuit via {H}igh-{D}ensity
                      {B}iosensors.},
      publisher    = {IEEE},
      reportid     = {DZNE-2026-00342},
      pages        = {1-4},
      year         = {2025},
      note         = {Missing Journal: Annu Int Conf IEEE Eng Med Biol Soc =
                      2375-7477 (import from CrossRef Conference, PubMed, ,
                      Journals: pub.dzne.de)},
      comment      = {2025 47th Annual International Conference of the IEEE
                      Engineering in Medicine and Biology Society (EMBC) :
                      [Proceedings] - IEEE, 2025. - ISBN 979-8-3315-8618-8 -
                      doi:10.1109/EMBC58623.2025.11253841},
      booktitle     = {2025 47th Annual International
                       Conference of the IEEE Engineering in
                       Medicine and Biology Society (EMBC) :
                       [Proceedings] - IEEE, 2025. - ISBN
                       979-8-3315-8618-8 -
                       doi:10.1109/EMBC58623.2025.11253841},
      abstract     = {70 million people suffer from epilepsy worldwide with
                      temporal lobe epilepsy (TLE) being the most common focal
                      epilepsy in adults. The hippocampus, a region associated
                      with TLE, is highly susceptible to pathological
                      synchronization and epileptogenesis due to its functional
                      and anatomical organization. Despite progress, understanding
                      the distinct contributions of hippocampal subregions to
                      multiplexed activation and hyperactivity remains challenging
                      due to the interplay of receptor dynamics, ion channel
                      regulation, and network synchronization. Here, a large-scale
                      ex-vivo electrophysiological platform was implemented using
                      a high-density CMOS-based biosensor (HD-MEA) to probe the
                      spatiotemporal dynamics of 4AP and ATPA, benchmark compounds
                      for inducing hyperactivity, within the hippocampal circuit.
                      This approach demonstrates the use of large-scale biosensors
                      to address these challenges by enabling high-resolution
                      spatiotemporal mapping of circuit activity, demonstrating
                      their potential to uncover ion channel and receptor-specific
                      spatiotemporal signatures of hyperactivity.},
      month         = {Jul},
      date          = {2025-07-14},
      organization  = {47th Annual International Conference
                       of the IEEE Engineering in Medicine and
                       Biology Society, Copenhagen (Denmark),
                       14 Jul 2025 - 18 Jul 2025},
      keywords     = {Biosensing Techniques: methods / Biosensing Techniques:
                      instrumentation / Hippocampus: physiopathology / Animals /
                      Epilepsy: physiopathology / Epilepsy, Temporal Lobe:
                      physiopathology / Spatio-Temporal Analysis / Humans},
      cin          = {AG Amin},
      cid          = {I:(DE-2719)1710010},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)8 / PUB:(DE-HGF)7},
      pubmed       = {pmid:41337179},
      doi          = {10.1109/EMBC58623.2025.11253841},
      url          = {https://pub.dzne.de/record/285806},
}