TY  - CONF
AU  - Hu, Xin
AU  - Khanzada, Shahrukh
AU  - Emery, Brett Addison
AU  - Amin, Hayder
TI  - A Computational Framework for Learning and Memory: Network Motif Evolution During LTP-Induced Plasticity.
PB  - IEEE
M1  - DZNE-2026-00343
SP  - 1-4
PY  - 2025
N1  - Missing Journal: Annu Int Conf IEEE Eng Med Biol Soc = 2375-7477 (import from CrossRef Conference, PubMed, , Journals: pub.dzne.de)
AB  - Unraveling the complexity of network-level synaptic plasticity remains a challenge due to the dynamic and interconnected nature of neural circuits. In this study, we employ network motifs-recurrent, functionally specialized patterns of connectivity-as a framework to dissect long-term potentiation (LTP)-induced reorganization in hippocampal CA1-CA3 networks. Using network LTP recordings from highdensity microelectrode arrays (HD-MEA), we systematically tracked motif evolution before and after high-frequency stimulation, assessing their roles in network stability, synaptic strength modulation, and criticality-redundancy trade-offs, linking these dynamics to firing synchrony and network potentiation. The Graph-theoretic analysis further demonstrated that LTP-induced reorganization follows a structured motif-guided trajectory, with early-phase motif recruitment optimizing efficiency, followed by phase-dependent refinement. These findings provide new insights into how structured connectivity enables network-level plasticity, balancing efficiency with stability, and offer a potential framework for understanding memory encoding mechanisms and their dysfunction in neurological disorders.
T2  - 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CY  - 14 Jul 2025 - 18 Jul 2025, Copenhagen (Denmark)
Y2  - 14 Jul 2025 - 18 Jul 2025
M2  - Copenhagen, Denmark
KW  - Long-Term Potentiation: physiology
KW  - Animals
KW  - Memory: physiology
KW  - Neuronal Plasticity: physiology
KW  - Learning: physiology
KW  - Models, Neurological
KW  - Rats
KW  - Nerve Net: physiology
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
C6  - pmid:41336996
DO  - DOI:10.1109/EMBC58623.2025.11254218
UR  - https://pub.dzne.de/record/285807
ER  -