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000285808 0247_ $$2doi$$a10.1109/EMBC58623.2025.11254514
000285808 0247_ $$2pmid$$apmid:41336611
000285808 037__ $$aDZNE-2026-00344
000285808 041__ $$aEnglish
000285808 1001_ $$0P:(DE-2719)9001867$$aKhanzada, Shahrukh$$b0$$eFirst author$$udzne
000285808 1112_ $$a47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society$$cCopenhagen$$d2025-07-14 - 2025-07-18$$gEMBC$$wDenmark
000285808 245__ $$aHigh-Density MEA Reveals Distinct Sharp-Wave Ripple Network Dynamics Across Induction Methods in the Hippocampus.
000285808 260__ $$bIEEE$$c2025
000285808 29510 $$a2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : [Proceedings] - IEEE, 2025. - ISBN 979-8-3315-8618-8 - doi:10.1109/EMBC58623.2025.11254514
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000285808 3367_ $$0PUB:(DE-HGF)8$$2PUB:(DE-HGF)$$aContribution to a conference proceedings$$bcontrib$$mcontrib$$s1775045310_18971
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000285808 500__ $$aMissing Journal: Annu Int Conf IEEE Eng Med Biol Soc = 2375-7477 (import from CrossRef Conference, PubMed, , Journals: pub.dzne.de)
000285808 520__ $$aLearning and memory are fundamental brain functions governed by rhythmic oscillatory activity, which synchronizes neural communication and modulates network dynamics. Distinct oscillatory patterns-theta (θ), beta (β), gamma (γ), and sharp wave-ripples (SWR)-coordinate neural ensemble activity, particularly in the hippocampal CA1-CA3 regions, where they play a crucial role in learning and memory. Understanding the mechanisms underlying SWR generation is crucial, as these oscillations play a fundamental role in memory consolidation, synaptic plasticity, and cognitive function. Unlike previous small-scale studies that relied on limited electrode coverage, our approach leverages high-density microelectrode arrays (HD-MEAs) to capture SWRs across large-scale hippocampal networks. This enables a direct comparison of how different induction methods influence network-wide dynamics, rather than focusing on isolated neuronal activity. By quantitatively assessing spatiotemporal propagation, frequency distributions, and ensemble synchronization, we aim to determine whether experimentally evoked SWRs truly replicate the functional characteristics of their spontaneous counterparts or introduce distinct network properties. Our findings provide a critical foundation for interpreting SWR activity in both physiological and experimental settings, offering novel insights into large-scale neural dynamics and their implications for memory-related processes and therapeutic interventions.
000285808 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000285808 588__ $$aDataset connected to CrossRef Conference, PubMed, , Journals: pub.dzne.de
000285808 650_2 $$2MeSH$$aHippocampus: physiology
000285808 650_2 $$2MeSH$$aAnimals
000285808 650_2 $$2MeSH$$aRats
000285808 650_2 $$2MeSH$$aNerve Net: physiology
000285808 650_2 $$2MeSH$$aMicroelectrodes
000285808 650_2 $$2MeSH$$aMale
000285808 650_2 $$2MeSH$$aNeurons: physiology
000285808 7001_ $$0P:(DE-2719)2814182$$aHu, Xin$$b1$$udzne
000285808 7001_ $$0P:(DE-2719)9001361$$aEmery, Brett Addison$$b2$$udzne
000285808 7001_ $$0P:(DE-2719)2812628$$aAmin, Hayder$$b3$$eLast author$$udzne
000285808 773__ $$a10.1109/EMBC58623.2025.11254514
000285808 8564_ $$uhttps://pub.dzne.de/record/285808/files/DZNE-2026-00344_Restricted.pdf
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000285808 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001867$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
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000285808 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812628$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
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000285808 9201_ $$0I:(DE-2719)1710010$$kAG Amin$$lBiohybrid Neuroelectronics (BIONICS)$$x0
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