%0 Conference Paper
%A Emery, Brett Addison
%A Khanzada, Shahrukh
%A Hu, Xin
%A Maggi, Maria Anna
%A Bisti, Silvia
%A Amin, Hayder
%T Network-Level Characterization of Hippocampal Disruptions in Alzheimer's Disease Using Large-Scale Electrophysiology.
%I IEEE
%M DZNE-2026-00345
%P 1-4
%D 2025
%Z Missing Journal: Annu Int Conf IEEE Eng Med Biol Soc = 2375-7477 (import from CrossRef Conference, PubMed, , Journals: pub.dzne.de)
%< 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) : [Proceedings] - IEEE, 2025. - ISBN 979-8-3315-8618-8 - doi:10.1109/EMBC58623.2025.11253272
%X Alzheimer's disease (AD), a progressive neurodegenerative disorder, is projected to affect over 130 million people globally by 2050. While extensive efforts have focused on targeting molecular hallmarks such as amyloid-beta (Aβ) plaques and tau pathology, network-level dysfunction remains a critical but underexplored component of AD progression. Disruptions in hippocampal-cortical (HC) circuit activity emerge early in AD, compromising memory processing and cognitive functions. Characterizing these disruptions requires high-resolution platforms capable of capturing network-wide spatiotemporal dynamics. To address this, we implemented a high-density microelectrode array (HD-MEA) biosensor to assess large-scale electrophysiological activity in ex vivo hippocampal slices from well-established APPNL and APPNL-G-F mouse models. Our approach quantifies hippocampal oscillatory disturbances and examines their modulation by saffron, a natural compound with reported neuroprotective properties. Results indicate that hippocampal network activity is progressively impaired in APPNL-G-F mice, particularly in sharp-wave ripple (SWR) and multi-unit activity (MUA) patterns. The HD-MEA platform provides a scalable tool for investigating AD-associated network dysfunctions and exploring potential modulatory interventions.
%B 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
%C 14 Jul 2025 - 18 Jul 2025, Copenhagen (Denmark)
Y2 14 Jul 2025 - 18 Jul 2025
M2 Copenhagen, Denmark
%K Alzheimer Disease: physiopathology
%K Hippocampus: physiopathology
%K Hippocampus: pathology
%K Animals
%K Mice
%K Mice, Transgenic
%K Disease Models, Animal
%K Microelectrodes
%K Electrophysiology: methods
%K Nerve Net: physiopathology
%K Humans
%F PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
%9 Contribution to a conference proceedingsContribution to a book
%$ pmid:41335966
%R 10.1109/EMBC58623.2025.11253272
%U https://pub.dzne.de/record/285809