TY  - CONF
AU  - Emery, Brett Addison
AU  - Khanzada, Shahrukh
AU  - Hu, Xin
AU  - Maggi, Maria Anna
AU  - Bisti, Silvia
AU  - Amin, Hayder
TI  - Network-Level Characterization of Hippocampal Disruptions in Alzheimer's Disease Using Large-Scale Electrophysiology.
PB  - IEEE
M1  - DZNE-2026-00345
SP  - 1-4
PY  - 2025
N1  - Missing Journal: Annu Int Conf IEEE Eng Med Biol Soc = 2375-7477 (import from CrossRef Conference, PubMed, , Journals: pub.dzne.de)
AB  - Alzheimer's disease (AD), a progressive neurodegenerative disorder, is projected to affect over 130 million people globally by 2050. While extensive efforts have focused on targeting molecular hallmarks such as amyloid-beta (Aβ) plaques and tau pathology, network-level dysfunction remains a critical but underexplored component of AD progression. Disruptions in hippocampal-cortical (HC) circuit activity emerge early in AD, compromising memory processing and cognitive functions. Characterizing these disruptions requires high-resolution platforms capable of capturing network-wide spatiotemporal dynamics. To address this, we implemented a high-density microelectrode array (HD-MEA) biosensor to assess large-scale electrophysiological activity in ex vivo hippocampal slices from well-established APPNL and APPNL-G-F mouse models. Our approach quantifies hippocampal oscillatory disturbances and examines their modulation by saffron, a natural compound with reported neuroprotective properties. Results indicate that hippocampal network activity is progressively impaired in APPNL-G-F mice, particularly in sharp-wave ripple (SWR) and multi-unit activity (MUA) patterns. The HD-MEA platform provides a scalable tool for investigating AD-associated network dysfunctions and exploring potential modulatory interventions.
T2  - 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CY  - 14 Jul 2025 - 18 Jul 2025, Copenhagen (Denmark)
Y2  - 14 Jul 2025 - 18 Jul 2025
M2  - Copenhagen, Denmark
KW  - Alzheimer Disease: physiopathology
KW  - Hippocampus: physiopathology
KW  - Hippocampus: pathology
KW  - Animals
KW  - Mice
KW  - Mice, Transgenic
KW  - Disease Models, Animal
KW  - Microelectrodes
KW  - Electrophysiology: methods
KW  - Nerve Net: physiopathology
KW  - Humans
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
C6  - pmid:41335966
DO  - DOI:10.1109/EMBC58623.2025.11253272
UR  - https://pub.dzne.de/record/285809
ER  -