Home > In process > Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model. > print

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037 _ _ |a DZNE-2026-00351
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Li, Tao
|b 0
245 _ _ |a Inflammasome adaptor ASC promotes sustained neuroinflammation and mild cognitive impairment in a closed-head injury model.
260 _ _ |a Ann Arbor, Mich.
|c 2026
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520 _ _ |a Mild traumatic brain injury (mTBI) from a closed-head injury (CHI) can lead to prevalent neuropsychiatric disorders, including mood disorders and an increased risk for neurodegenerative diseases and dementia. Inflammasomes are molecular complexes crucial for neuroinflammation and secondary damage after trauma, however their role in mild CHI (mCHI) is poorly understood. In this study, we investigate the cellular expression of inflammasome-related genes and their functional significance in CHI models. Single-cell RNA-seq analysis of cortical tissue after trauma revealed selective expression of Asc (also known as Pycard), which encodes the inflammasome adaptor apoptosis-associated Speck-like protein containing a caspase recruitment domain (ASC), predominantly in microglial clusters. Sustained upregulation of inflammasome-related proteins, microglia activation, and astrocyte reactivity persisted up to 21 days in a model for mTBI, with significant reduction of this pattern in Asc-/- mice. Importantly, mild cognitive impairment induced after mCHI was largely abrogated in Asc-/- mice. These findings suggest that ASC, as the primary inflammasome adaptor, plays a critical role in sustaining neuroinflammation and contributes to cognitive deficits after mCHI. This study provides insights into the molecular neuroinflammatory mechanisms underlying CHI, potentially informing future therapeutic strategies.
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650 _ 7 |a Dementia
|2 Other
650 _ 7 |a Inflammation
|2 Other
650 _ 7 |a Innate immunity
|2 Other
650 _ 7 |a Neuroscience
|2 Other
650 _ 7 |a Transcriptomics
|2 Other
650 _ 7 |a CARD Signaling Adaptor Proteins
|2 NLM Chemicals
650 _ 7 |a Inflammasomes
|2 NLM Chemicals
650 _ 7 |a Pycard protein, mouse
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a CARD Signaling Adaptor Proteins: genetics
|2 MeSH
650 _ 2 |a CARD Signaling Adaptor Proteins: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: metabolism
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: genetics
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: etiology
|2 MeSH
650 _ 2 |a Inflammasomes: genetics
|2 MeSH
650 _ 2 |a Inflammasomes: metabolism
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: pathology
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: metabolism
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: genetics
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: etiology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Brain Concussion: pathology
|2 MeSH
650 _ 2 |a Brain Concussion: genetics
|2 MeSH
650 _ 2 |a Brain Concussion: metabolism
|2 MeSH
650 _ 2 |a Microglia: pathology
|2 MeSH
650 _ 2 |a Microglia: metabolism
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
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700 1 _ |a Castro-Gomez, Mario Sergio
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700 1 _ |a Botella Lucena, Pablo
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700 1 _ |a Vieira-Saecker, Ana
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700 1 _ |a Schwartz, Stephanie
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700 1 _ |a Ding, Yingying
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700 1 _ |a Deng, Yushuang
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700 1 _ |a Gou, Maling
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700 1 _ |a Stein, Valentin
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700 1 _ |a Golenbock, Douglas T
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700 1 _ |a Latz, Eicke
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700 1 _ |a Heneka, Michael T
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773 _ _ |a 10.1172/JCI199818
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