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@ARTICLE{Goodwin:285816,
      author       = {Goodwin, Elizabeth and Michalowsky, Bernhard and Middleton,
                      Rod and Hawton, Annie},
      title        = {{M}easuring health-related quality of life in multiple
                      sclerosis: comparing the acceptability, validity and
                      responsiveness of the {EQ}-5{D}-3{L} and {MSIS}-8{D}.},
      journal      = {Quality of life research},
      volume       = {35},
      number       = {5},
      issn         = {0962-9343},
      address      = {Cham},
      publisher    = {Springer Nature Switzerland AG},
      reportid     = {DZNE-2026-00352},
      pages        = {124},
      year         = {2026},
      abstract     = {Purpose: Concerns have been raised about the sensitivity
                      and responsiveness of the EQ-5D, one of the most commonly
                      used preference-based health-related quality of life
                      measures, in the context of multiple sclerosis (MS). In
                      response to these concerns, a condition-specific
                      preference-based measure, the Multiple Sclerosis Impact
                      Scale Eight Dimensions (MSIS-8D), was developed. This
                      research aimed to assess the psychometric and distributional
                      properties of the MSIS-8D compared to the EQ-5D-3L, in
                      people with MS. Methods: Analyses were undertaken using data
                      from the UK MS Register. Both measures were compared in
                      terms of acceptability (missing data), distributional
                      properties (health state frequencies, health state density
                      curves and indices), construct validity in relation to
                      disability, mobility, fatigue, anxiety and depression
                      (discriminative and convergent validity, using ANOVA,
                      independent t-tests and Spearman correlations), and
                      responsiveness to symptom onset and relapse (mean change
                      scores, standardised response means, standardised effect
                      sizes, paired t-tests). Results: The MSIS-8D exhibited
                      superior distributional properties, while the EQ-5D-3L
                      showed greater acceptability. Both measures demonstrated
                      excellent construct validity. Neither measure appeared
                      responsive to symptom onset, and only the MSIS-8D met all
                      criteria for responsiveness when people moved from a
                      non-relapse to a relapse state. Conclusion: Although the
                      MSIS-8D appears to offer superior distributional properties
                      and responsiveness compared to the EQ-5D-3L, the
                      responsiveness of both measures in this analysis was
                      limited. This adds weight to existing concerns about the
                      ability of utility measures used in healthcare
                      decision-making to fully capture treatment effects in MS.},
      keywords     = {EQ-5D (Other) / Economic evaluation (Other) /
                      Health-related quality of life (Other) / Multiple sclerosis
                      (Other) / Preference-based measures (Other) / Psychometrics
                      (Other)},
      cin          = {AG Michalowsky},
      ddc          = {100},
      cid          = {I:(DE-2719)5000067},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41920450},
      doi          = {10.1007/s11136-026-04229-5},
      url          = {https://pub.dzne.de/record/285816},
}