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024 7 _ |a 10.1016/j.neurot.2026.e00864
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024 7 _ |a 1933-7213
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024 7 _ |a 1545-5343
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024 7 _ |a 1545-5351
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024 7 _ |a 1878-7479
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037 _ _ |a DZNE-2026-00361
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Liu, Jinlong
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245 _ _ |a Functional network reorganization following VIM-MRgFUS for essential tremor.
260 _ _ |a [Amsterdam]
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520 _ _ |a Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising, noninvasive therapeutic approach for essential tremor (ET), yet the effects of the respective lesions on functional brain network organization remain poorly understood. Here, we performed graph theory analysis to investigate changes in small-world properties and modular architecture in ET patients six months after unilateral MRgFUS of the thalamic ventral intermediate (VIM) nucleus. Small-worldness and normalized clustering coefficient increased significantly after MRgFUS, while clustering coefficient, characteristic path length, normalized characteristic path length, global efficiency, and local efficiency remained unchanged. Modular organization was largely preserved, but trend-level enhancements in inter-modular connectivity were observed between frontoparietal and subcortical modules, as well as between frontoparietal and frontotemporal-parietal modules. Within these modules, betweenness centrality increased significantly in specific cortical hubs, including the left superior frontal gyrus, right superior parietal lobule, and left postcentral gyrus. These findings indicate that unilateral VIM-MRgFUS induces selective functional network reorganization, particularly affecting relative clustering and nodal centrality patterns.
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650 _ 7 |a Brain networks
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650 _ 7 |a Essential tremor
|2 Other
650 _ 7 |a Graph theory analysis
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650 _ 7 |a MRgFUS
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650 _ 7 |a Ventral intermediate nucleus
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Essential Tremor: diagnostic imaging
|2 MeSH
650 _ 2 |a Essential Tremor: therapy
|2 MeSH
650 _ 2 |a Essential Tremor: physiopathology
|2 MeSH
650 _ 2 |a Essential Tremor: surgery
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging: methods
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Ventral Thalamic Nuclei: diagnostic imaging
|2 MeSH
650 _ 2 |a Ventral Thalamic Nuclei: surgery
|2 MeSH
650 _ 2 |a Nerve Net: diagnostic imaging
|2 MeSH
700 1 _ |a Krauss, Jonas
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700 1 _ |a Purrer, Veronika
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700 1 _ |a Borger, Valeri
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700 1 _ |a Essler, Markus
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700 1 _ |a Radbruch, Alexander
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700 1 _ |a Wüllner, Ullrich
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700 1 _ |a Upadhyay, Neeraj
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700 1 _ |a Boecker, Henning
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773 _ _ |a 10.1016/j.neurot.2026.e00864
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