TY  - JOUR
AU  - Pietrock, Charlotte
AU  - Neumann, Konrad
AU  - Rentzsch, Kristin
AU  - Prüss, Harald
AU  - Meisel, Andreas
AU  - Endres, Matthias
AU  - Nave, Alexander Heinrich
TI  - Neuronal autoantibodies associated with poorer neuropsychological and motor outcomes 6 months after stroke: results from the PHYS-STROKE trial.
JO  - Frontiers in immunology
VL  - 16
SN  - 1664-3224
CY  - Lausanne
PB  - Frontiers Media
M1  - DZNE-2026-00363
SP  - 1678840
PY  - 2026
N1  - Trial registration: clinicaltrials.gov NCT01953549
AB  - Emerging evidence suggests a role of neuronal autoantibodies (nAbs) for long-term stroke outcomes. However, data remain limited and many domains unexamined. We present a comprehensive analysis of nAbs and their association with a broad range of outcome measures at multiple timepoints in the six months following moderate stroke.In this explorative analysis of the multicenter, randomized-controlled PHYS-STROKE trial, serum samples from stroke patients were tested for 40 nAbs at baseline (5-45 days post-stroke), post-intervention (4 weeks after baseline), and at three and six months after stroke. Generalized estimating equation (GEE)-models were used to evaluate the dynamics of nAbs over time. Multiple linear regression models were applied to investigate the prognostic role of nAbs on various outcomes at three and six months.Two hundred stroke patients (41
KW  - Humans
KW  - Autoantibodies: blood
KW  - Autoantibodies: immunology
KW  - Female
KW  - Male
KW  - Aged
KW  - Stroke: immunology
KW  - Stroke: blood
KW  - Stroke: psychology
KW  - Middle Aged
KW  - Neurons: immunology
KW  - Aged, 80 and over
KW  - Prognosis
KW  - Neuropsychological Tests
KW  - Biomarkers: blood
KW  - NMDAR (Other)
KW  - biomarker (Other)
KW  - neuroimmunology (Other)
KW  - neuronal autoantibodies (Other)
KW  - outcome (Other)
KW  - recovery (Other)
KW  - stroke (Other)
KW  - Autoantibodies (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41929475
C2  - pmc:PMC13038563
DO  - DOI:10.3389/fimmu.2025.1678840
UR  - https://pub.dzne.de/record/285917
ER  -