%0 Journal Article
%A Kransberg, Jonas
%A Sjøli Bråthen, Anne Cecilie
%A Falch, Emilie Sogn
%A Øverbye, Knut E. Ø.
%A Garrido, Pablo F.
%A Fjell, Anders M.
%A Stangl, Matthias
%A Wolbers, Thomas
%A Sneve, Markus H.
%A Walhovd, Kristine B.
%T Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study
%J Imaging neuroscience
%V 4
%@ 2837-6056
%C Cambridge, MA
%I MIT Press
%M DZNE-2026-00366
%P IMAG.a.1196
%D 2026
%X Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer’s disease. This pre-registered functional magnetic resonance imaging (fMRI) study aimed to detect grid-cell-like signals (GLS) in a passive virtual navigation task. Contrary to our hypotheses and previous findings, we did not observe significant GLS at a population level, even in younger participants. Further exploratory analyses investigated the impact of task-engagement, as inferred from object-location memory performance, and showed no relationship with GLS magnitude. We also examined potential influences of a confounding one-fold directional signal and various data-processing choices but observed no consistent patterns. Our findings, consistent with recent null results from similar studies, suggest that passive navigation paradigms may be insufficient for reliably eliciting grid-like signals in human fMRI.
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1162/IMAG.a.1196
%U https://pub.dzne.de/record/285920