TY  - JOUR
AU  - Kransberg, Jonas
AU  - Sjøli Bråthen, Anne Cecilie
AU  - Falch, Emilie Sogn
AU  - Øverbye, Knut E. Ø.
AU  - Garrido, Pablo F.
AU  - Fjell, Anders M.
AU  - Stangl, Matthias
AU  - Wolbers, Thomas
AU  - Sneve, Markus H.
AU  - Walhovd, Kristine B.
TI  - Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study
JO  - Imaging neuroscience
VL  - 4
SN  - 2837-6056
CY  - Cambridge, MA
PB  - MIT Press
M1  - DZNE-2026-00366
SP  - IMAG.a.1196
PY  - 2026
AB  - Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer’s disease. This pre-registered functional magnetic resonance imaging (fMRI) study aimed to detect grid-cell-like signals (GLS) in a passive virtual navigation task. Contrary to our hypotheses and previous findings, we did not observe significant GLS at a population level, even in younger participants. Further exploratory analyses investigated the impact of task-engagement, as inferred from object-location memory performance, and showed no relationship with GLS magnitude. We also examined potential influences of a confounding one-fold directional signal and various data-processing choices but observed no consistent patterns. Our findings, consistent with recent null results from similar studies, suggest that passive navigation paradigms may be insufficient for reliably eliciting grid-like signals in human fMRI.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1162/IMAG.a.1196
UR  - https://pub.dzne.de/record/285920
ER  -