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| 037 | _ | _ | |a DZNE-2026-00366 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Kransberg, Jonas |0 0000-0001-9770-8360 |b 0 |
| 245 | _ | _ | |a Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study |
| 260 | _ | _ | |a Cambridge, MA |c 2026 |b MIT Press |
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| 520 | _ | _ | |a Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer’s disease. This pre-registered functional magnetic resonance imaging (fMRI) study aimed to detect grid-cell-like signals (GLS) in a passive virtual navigation task. Contrary to our hypotheses and previous findings, we did not observe significant GLS at a population level, even in younger participants. Further exploratory analyses investigated the impact of task-engagement, as inferred from object-location memory performance, and showed no relationship with GLS magnitude. We also examined potential influences of a confounding one-fold directional signal and various data-processing choices but observed no consistent patterns. Our findings, consistent with recent null results from similar studies, suggest that passive navigation paradigms may be insufficient for reliably eliciting grid-like signals in human fMRI. |
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| 700 | 1 | _ | |a Sjøli Bråthen, Anne Cecilie |0 0000-0002-5118-0000 |b 1 |
| 700 | 1 | _ | |a Falch, Emilie Sogn |0 0009-0000-0813-4394 |b 2 |
| 700 | 1 | _ | |a Øverbye, Knut E. Ø. |0 0000-0003-0809-960X |b 3 |
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