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@ARTICLE{StreckfussBmeke:286086,
      author       = {Streckfuss-Bömeke, Katrin and Zelarayán, Laura C and
                      Schnabel, Renate B and Kränkel, Nicolle and Maack,
                      Christoph and Eschenhagen, Thomas and Kappler, Hannah E and
                      Klingmüller, Ursula and Kramann, Rafael and Loewe, Axel and
                      Milting, Hendrik and Molina, Cristina E and Panáková,
                      Daniela and Podesser, Bruno K and Schnieke, Angelika and
                      Schröder, Katrin and Seidel, Thomas and Sossalla, Samuel
                      and Zgierski-Johnston, Callum and Zimmermann,
                      Wolfram-Hubertus and Rog-Zielinska, Eva A and Kohl, Peter},
      title        = {{M}odels of the human heart for biomedical research:
                      {O}pportunities and challenges.},
      journal      = {Physiological reports},
      volume       = {14},
      number       = {7},
      issn         = {2051-817X},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Wiley},
      reportid     = {DZNE-2026-00382},
      pages        = {e70845},
      year         = {2026},
      abstract     = {Model systems that mimic human cardiac structure and
                      function are essential for the development of novel
                      diagnostics and effective treatments for cardiovascular
                      diseases. While non-human vertebrate models, from zebrafish
                      to pig, remain vital to cardiovascular research, the
                      translatability of findings to human patients is often
                      limited. Therefore, animal experiments should be
                      supplemented with human model systems, including human
                      induced pluripotent stem cell-derived cells, 3D engineered
                      constructs, and last but not least, native tissue
                      preparations and isolated primary cardiomyocytes. However,
                      while human myocardium remains the gold standard, human
                      heart tissue - and particularly tissue from control
                      hearts-remains scarce, and its use in research is generally
                      restricted to settings where tissue has been excised from
                      diseased or failing hearts. While it is in principle
                      possible to use tissue from rejected non-failing donor
                      hearts that cannot be transplanted, legal hurdles (e.g., in
                      Germany) can restrict the use of non-transplanted donor
                      organs in research. Given the challenges associated with
                      accessing and using human tissue in biomedical research, an
                      integrated strategy towards combining non-human vertebrate
                      models, in silico models, and human tissue-derived models is
                      recommended, enhancing the chances of successful research
                      and development, and helping bridge the gap between
                      preclinical and clinical research.},
      subtyp        = {Review Article},
      keywords     = {Humans / Biomedical Research: methods / Animals / Heart:
                      physiology / Myocytes, Cardiac / Induced Pluripotent Stem
                      Cells / animal models (Other) / donor tissue (Other) / human
                      myocardium (Other) / stem cell models (Other) / vertebrate
                      models (Other)},
      cin          = {AG Fischer},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41954020},
      pmc          = {pmc:PMC13062934},
      doi          = {10.14814/phy2.70845},
      url          = {https://pub.dzne.de/record/286086},
}