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@ARTICLE{Czajka:286088,
      author       = {Czajka, Titus and Major, Andras and Bruns, Hendrik and
                      Cammarata, Marco and Hoffmann, Christian and Milovanovic,
                      Dragomir and Salditt, Tim},
      title        = {{V}esicle dynamics in synapsin-induced condensates by
                      passive {X}-ray microrheology.},
      journal      = {Biophysical journal},
      volume       = {125},
      number       = {7},
      issn         = {0006-3495},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DZNE-2026-00384},
      pages        = {1713 - 1722},
      year         = {2026},
      abstract     = {The collective dynamics of subcellular biological processes
                      is often difficult to assess experimentally due to the
                      challenges associated with spatial and temporal resolution,
                      labeling, or multiple scattering. X-ray photon correlation
                      spectroscopy is, in principle, well suited to probe
                      collective dynamics by quantifying dispersion relations in
                      complex fluids in general and biomolecular systems in
                      particular. However, the low scattering signal and the
                      sensitivity to radiation damage set stringent limits to many
                      applications. Probing the dynamics of vesicles in
                      protein-induced condensates is a case in point. Here, we use
                      lipid vesicles with a hard silica core, called
                      colloid-supported lipid bilayers, as labeled vesicles for
                      enhanced X-ray contrast. We then probe structure and
                      dynamics in solutions of vesicles and synapsin, a protein
                      known for its property of inducing liquid-liquid phase
                      separation and forming condensates that recruit vesicles,
                      organizing them into clusters in presynaptic nerve
                      terminals. The dynamics in these systems is found to exhibit
                      evidence for both liquid-like and network-like phases. Our
                      results reveal distinct effective-diffusion constants at
                      varying protein concentrations. At the same time the
                      stretched exponential decay of the correlation functions
                      provides clear evidence for nondiffusive behavior within the
                      condensates.},
      keywords     = {Lipid Bilayers: chemistry / Lipid Bilayers: metabolism /
                      Synapsins: metabolism / Synapsins: chemistry / Diffusion /
                      X-Rays / Biomolecular Condensates: chemistry / Biomolecular
                      Condensates: metabolism / Lipid Bilayers (NLM Chemicals) /
                      Synapsins (NLM Chemicals)},
      cin          = {AG Milovanovic (Berlin)},
      ddc          = {570},
      cid          = {I:(DE-2719)1813002},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41795188},
      doi          = {10.1016/j.bpj.2026.03.006},
      url          = {https://pub.dzne.de/record/286088},
}