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000286089 1001_ $$0P:(DE-2719)9001438$$aPradhan, Ranjit$$b0$$eFirst author$$udzne
000286089 245__ $$alncRNA Glelr modulates microglia inflammatory programs in association with PU.1.
000286089 260__ $$a[Amsterdam]$$bElsevier$$c2026
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000286089 520__ $$aLong non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to microglial aging and neurodegenerative disease remains largely unknown. Because only 1.5% of the human genome encodes proteins, whereas the vast majority of transcripts belong to the largely unexplored non-coding RNAome, elucidating the functions of non-coding RNAs provides an unprecedented opportunity to expand the space for therapeutic discovery. We recently identified the glia-enriched lncRNA Glelr as upregulated in the aging mouse hippocampus. Here, we investigated its function in microglia and its human homolog GLELR. We found that Glelr/GLELR is expressed in both astrocytes and microglia and increases with age. Knockdown of Glelr in primary microglia led to enhanced expression of pro-inflammatory cytokines, including TNFα, and increased phagocytic activity. RNA-sequencing revealed widespread transcriptional changes enriched for TNF and complement signaling pathways. The human homolog GLELR showed conserved functions in iPSC-derived microglia, where its loss similarly promoted inflammatory gene expression and phagocytosis. Mechanistically, Glelr interacts with the microglial transcription factor PU.1, and its depletion overlapped with PU.1-driven transcriptional programs. Consistent with these findings, GLELR expression was significantly reduced in postmortem Alzheimer's disease (AD) brains, and AD-associated genes were enriched among Glelr-regulated targets. Together, our results identify Glelr/GLELR as a conserved, aging-associated lncRNA that modulates microglial inflammatory states through interaction with PU.1. This work links glial lncRNA regulation to AD-related neuroinflammation and suggests GLELR as a potential molecular target to fine-tune microglial activity in neurodegenerative diseases.
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000286089 650_7 $$2Other$$a3222401L13Rik/ENSG00000272070
000286089 650_7 $$2Other$$aAlzheimer's disease
000286089 650_7 $$2Other$$aLong non-coding RNA (lncRNA)
000286089 650_7 $$2Other$$aMicroglia
000286089 650_7 $$2Other$$aNeuroinflammation
000286089 650_7 $$2Other$$aNon-coding RNAome
000286089 650_7 $$2Other$$aPU.1 (SPI1)
000286089 650_7 $$2NLM Chemicals$$aRNA, Long Noncoding
000286089 650_7 $$2NLM Chemicals$$aTrans-Activators
000286089 650_7 $$2NLM Chemicals$$aProto-Oncogene Proteins
000286089 650_2 $$2MeSH$$aRNA, Long Noncoding: metabolism
000286089 650_2 $$2MeSH$$aRNA, Long Noncoding: genetics
000286089 650_2 $$2MeSH$$aMicroglia: metabolism
000286089 650_2 $$2MeSH$$aAnimals
000286089 650_2 $$2MeSH$$aHumans
000286089 650_2 $$2MeSH$$aMice
000286089 650_2 $$2MeSH$$aTrans-Activators: metabolism
000286089 650_2 $$2MeSH$$aTrans-Activators: genetics
000286089 650_2 $$2MeSH$$aProto-Oncogene Proteins: metabolism
000286089 650_2 $$2MeSH$$aProto-Oncogene Proteins: genetics
000286089 650_2 $$2MeSH$$aInflammation: metabolism
000286089 650_2 $$2MeSH$$aInflammation: genetics
000286089 650_2 $$2MeSH$$aMice, Inbred C57BL
000286089 650_2 $$2MeSH$$aCells, Cultured
000286089 650_2 $$2MeSH$$aAging: metabolism
000286089 650_2 $$2MeSH$$aAstrocytes: metabolism
000286089 7001_ $$0P:(DE-2719)2812054$$aSakib, M Sadman$$b1$$udzne
000286089 7001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b2$$udzne
000286089 7001_ $$0P:(DE-2719)2812548$$aKrüger, Dennis M$$b3$$udzne
000286089 7001_ $$0P:(DE-2719)2811063$$aPena, Tonatiuh$$b4$$udzne
000286089 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b5$$udzne
000286089 7001_ $$0P:(DE-2719)2810585$$aSchütz, Anna-Lena$$b6$$udzne
000286089 7001_ $$0P:(DE-2719)9001451$$aKronenberg-Versteeg, Deborah$$b7$$udzne
000286089 7001_ $$0P:(DE-HGF)0$$aDelalle, Ivana$$b8
000286089 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b9$$udzne
000286089 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b10$$eLast author$$udzne
000286089 773__ $$0PERI:(DE-600)1471408-5$$a10.1016/j.nbd.2026.107366$$gVol. 222, p. 107366 -$$p107366$$tNeurobiology of disease$$v222$$x0969-9961$$y2026
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