%0 Journal Article
%A Halbgebauer, Steffen
%A Winger, Niklas
%A Elmas, Zeynep
%A Fazeli, Badrieh
%A Bachhuber, Franziska
%A Erhart, Deborah K
%A Soylu, Önder
%A Klassen, Paula
%A Senel, Makbule
%A Dorst, Johannes
%A Haeusler, Karl Georg
%A Weishaupt, Jochen H
%A Otto, Markus
%A Tumani, Hayrettin
%T Distinct cerebrospinal fluid profiles of astrocytic aquaporin-4 and GFAP in neuroinflammatory disorders.
%J Neurobiology of disease
%V 222
%@ 0969-9961
%C [Amsterdam]
%I Elsevier
%M DZNE-2026-00389
%P 107351
%D 2026
%X Aquaporin 4 (AQP4), a water channel expressed in astrocytic end feet forming the blood brain barrier, is predominantly expressed in the central nervous system. Cerebrospinal fluid (CSF) AQP4 has now been suggested as a possible fluid biomarker in Alzheimer's disease. However, its diagnostic potential in primary neuroinflammatory diseases, where also AQP4 autoantibodies can circulate, has so far not been studied. We investigated the CSF of 301 patients for AQP4 and GFAP using ELISA. The single-center cohort consisted of patients with multiple sclerosis (n = 81), chronic inflammatory demyelinating polyneuropathy (n = 23), Guillain-Barré-Syndrome (n = 13), meningitis/ encephalitis (Men/Enc) (n = 19), myelin oligodendrocyte glycoprotein antibody disease (n = 6), neuromyelitis optica spectrum disease (NMOSD) (n = 12), and non-immune mediated polyneuropathy (NIP) patients (n = 49). 98 patients without acute or chronic neuroinflammation and neurodegneration served as controls. Both CSF AQP4 (r = 0.45 (95
%K Humans
%K Aquaporin 4: cerebrospinal fluid
%K Male
%K Female
%K Middle Aged
%K Adult
%K Biomarkers: cerebrospinal fluid
%K Astrocytes: metabolism
%K Glial Fibrillary Acidic Protein: cerebrospinal fluid
%K Aged
%K Neuroinflammatory Diseases: cerebrospinal fluid
%K Neuroinflammatory Diseases: diagnosis
%K Cohort Studies
%K Young Adult
%K Autoantibodies: cerebrospinal fluid
%K Aquaporin 4 (Other)
%K Astrocytes (Other)
%K Biomarker (Other)
%K Cerebrospinal fluid (Other)
%K GFAP (Other)
%K Aquaporin 4 (NLM Chemicals)
%K AQP4 protein, human (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Glial Fibrillary Acidic Protein (NLM Chemicals)
%K GFAP protein, human (NLM Chemicals)
%K Autoantibodies (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41831579
%R 10.1016/j.nbd.2026.107351
%U https://pub.dzne.de/record/286093