TY  - JOUR
AU  - Halbgebauer, Steffen
AU  - Winger, Niklas
AU  - Elmas, Zeynep
AU  - Fazeli, Badrieh
AU  - Bachhuber, Franziska
AU  - Erhart, Deborah K
AU  - Soylu, Önder
AU  - Klassen, Paula
AU  - Senel, Makbule
AU  - Dorst, Johannes
AU  - Haeusler, Karl Georg
AU  - Weishaupt, Jochen H
AU  - Otto, Markus
AU  - Tumani, Hayrettin
TI  - Distinct cerebrospinal fluid profiles of astrocytic aquaporin-4 and GFAP in neuroinflammatory disorders.
JO  - Neurobiology of disease
VL  - 222
SN  - 0969-9961
CY  - [Amsterdam]
PB  - Elsevier
M1  - DZNE-2026-00389
SP  - 107351
PY  - 2026
AB  - Aquaporin 4 (AQP4), a water channel expressed in astrocytic end feet forming the blood brain barrier, is predominantly expressed in the central nervous system. Cerebrospinal fluid (CSF) AQP4 has now been suggested as a possible fluid biomarker in Alzheimer's disease. However, its diagnostic potential in primary neuroinflammatory diseases, where also AQP4 autoantibodies can circulate, has so far not been studied. We investigated the CSF of 301 patients for AQP4 and GFAP using ELISA. The single-center cohort consisted of patients with multiple sclerosis (n = 81), chronic inflammatory demyelinating polyneuropathy (n = 23), Guillain-Barré-Syndrome (n = 13), meningitis/ encephalitis (Men/Enc) (n = 19), myelin oligodendrocyte glycoprotein antibody disease (n = 6), neuromyelitis optica spectrum disease (NMOSD) (n = 12), and non-immune mediated polyneuropathy (NIP) patients (n = 49). 98 patients without acute or chronic neuroinflammation and neurodegneration served as controls. Both CSF AQP4 (r = 0.45 (95
KW  - Humans
KW  - Aquaporin 4: cerebrospinal fluid
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Adult
KW  - Biomarkers: cerebrospinal fluid
KW  - Astrocytes: metabolism
KW  - Glial Fibrillary Acidic Protein: cerebrospinal fluid
KW  - Aged
KW  - Neuroinflammatory Diseases: cerebrospinal fluid
KW  - Neuroinflammatory Diseases: diagnosis
KW  - Cohort Studies
KW  - Young Adult
KW  - Autoantibodies: cerebrospinal fluid
KW  - Aquaporin 4 (Other)
KW  - Astrocytes (Other)
KW  - Biomarker (Other)
KW  - Cerebrospinal fluid (Other)
KW  - GFAP (Other)
KW  - Aquaporin 4 (NLM Chemicals)
KW  - AQP4 protein, human (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - GFAP protein, human (NLM Chemicals)
KW  - Autoantibodies (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41831579
DO  - DOI:10.1016/j.nbd.2026.107351
UR  - https://pub.dzne.de/record/286093
ER  -